On February 14, 2018, Peters, David S.; Romesberg, Floyd E.; Baran, Phil S. published an article.Synthetic Route of 32462-30-9 The title of the article was Scalable access to arylomycins via C-H functionalization logic. And the article contained the following:
Arylomycins are a promising class of “latent” antibacterial natural products currently in preclin. development. Access to analogs within this family has previously required a lengthy route involving multiple functional group manipulations that is costly and time-intensive on scale. This study presents a simplified route predicated on simple C-H functionalization logic that is enabled by a Cu-mediated oxidative phenol coupling that mimics the putative biosynthesis. This operationally simple macrocyclization is the largest of its kind and can be easily performed on gram scale. The application of this new route to a formal synthesis of the natural product and a collection of new analogs along with their biol. evaluation is also reported. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Synthetic Route of 32462-30-9
The Article related to natural product arylomycin analog synthesis antibacterial structure activity antibiotic, oxidative phenol coupling copper catalyst macrocyclization solvent effect, mol docking ligand protein interaction and other aspects.Synthetic Route of 32462-30-9
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