On June 13, 1979, Ong, Helen Hu; Anderson, Vernon Brian; Profitt, James Arthur published a patent.Name: (2-Fluorophenyl)methanethiol The title of the patent was Substituted 1,3-dihydrospirobenzo[c]thiophenes. And the patent contained the following:
Antidepressant spirobenzothiophenes I (R = optionally substituted Ph; R1 = H, alkyl, alkoxy, CF3, Cl, Br, F, OH, OCH2O, alkylthio; R2 = H, OH, acyloxy, optionally substituted alkyl; m, n = 1-3; m + n = 3,4) were prepared Thus, 2-BrC6H4F (in THF containing BuLi) was treated with 1-methyl-4-piperidinone to give II (R3 = OH), which was treated with PhCH2SH to give II (R3 = SCH2Ph). The latter compound was cyclized with NaH-Me2SO to give III which had a ED50 of 2.8 mg/kg i.p. in mice against tetrabenazine-induced ptosis. I also have tranquilizing activity of 0.1-50 mg/kg in the Sidman avoidance paradigim test. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Name: (2-Fluorophenyl)methanethiol
The Article related to spirobenzothiophenepiperidine preparation antidepressant, antidepressant spirobenzothiophenepiperidine, tranquilizer spirobenzothiophenepiperidine, benzothiophene spiropiperidine preparation antidepressant, piperidine spirobenzothiophene preparation antidepressant and other aspects.Name: (2-Fluorophenyl)methanethiol
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