On May 8, 2003, Minich, Martha Lou; Rast, Bryson; Sakya, Subas Man; Sahvnya, Andrei published a patent.Computed Properties of 72364-46-6 The title of the patent was An efficient synthesis of 1-[sulfonylphenyl(or pyridyl)] pyrazoles as COX-2 inhibitors. And the patent contained the following:
The title compounds [I; the ring of the formula (R5)-A-(SOmR4) = II-VIII; m = 0-2; X = CR5, N; R1 = H, NO2, CN, etc.; R2 = H, NO2, CN, etc.; R3 = NR6NR7R8, NR6OR7, OR7, SR7, NR7R8 (wherein R6 = H, alkyl, alkenyl, etc.; or R6 and R7 may optionally taken together with the N atom or O atom to which they are attached to form 3-8 membered heterocyclyl ring; R8 = H, alkyl, alkenyl, etc.; or NR7R8 = 3-8 membered heterocyclyl); R4 = NH2, mono- and dialkylamino, etc.; R5 = H, halo, OH, etc.], useful as antiinflammatory/analgesic agents, were prepared by reacting a compound IX [the ring of the formula (R5)-A-(SOmR4), m, R1-R8 are as defined above and R10 = halo, alkylSO3, arylSO3, alkylSO2, arylSO2; wherein each of said alkyl components may optionally be substituted on any carbon atom by 1-6 fluoro substituents per alkyl component] with a compound R3H [R3 is as defined above] in the presence of a fluoride containing salt and in the presence of a solvent. Thus, reacting 5-chloro-1-(5-methanesulfonylpyridin-2-yl)-3-trifluoromethyl-1H-pyrazole-4-carbonitrile with (4-methylenecyclohexyl)methanol in the presence of KF in DMSO afforded 68% the pyrazole X. Most compounds prepared in Examples showed IC50 values of 0.001 μM to 3 μM with respect to inhibition of COX-2 in either the canine or human assays. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Computed Properties of 72364-46-6
The Article related to sulfonylphenylpyrazole sulfonylpyridylpyrazole preparation cyclooxygenase cox2 inhibitor, pyrazole sulfonylphenyl sulfonylpyridyl preparation cyclooxygenase cox2 inhibitor antiinflammatory analgesic and other aspects.Computed Properties of 72364-46-6
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