Masip, Jenifer; Rallon, Norma; Yeregui, Elena; Olona, Montserrat; Resino, Salvador; Benito, Jose M.; Vilades, Consuelo; Garcia-Pardo, Graciano; Alcami, Jose; Ruiz-Mateos, Ezequiel; Gomez-Bertomeu, Frederic; Vargas, Montserrat; Navarro, Marta; Oteo, Jose A.; Pineda, Juan A.; Marti, Anna; Alba, Veronica; Vidal, Francesc; Peraire, Joaquin; Rull, Anna; ECRIS Integrated In The Spanish AIDS Research Network published an article in 2022, the title of the article was Elevated α-ketoglutaric acid concentrations and a lipid-balanced signature are the key factors in long-term HIV control.Name: 2,3-Dihydroxypropanoic acid And the article contains the following content:
Long-term elite controllers (LTECs) are a fascinating small subset of HIV individuals with viral and immunol. HIV control in the long term that have been designated as models of an HIV functional cure. However, data on the LTEC phenotype are still scarce, and hence, the metabolomics and lipidomics signatures in the LTEC-extreme phenotype, LTECs with more than 10 years of viral and immunol. HIV control, could be pivotal to finding the keys for functional HIV remission. Metabolomics and lipidomics analyses were performed using high-resolution mass spectrometry (ultra-high-performance liquid chromatog.-electrospray ionization-quadrupole time of flight [UHPLC-(ESI) qTOF])in plasma samples of 13 patients defined as LTEC-extreme, a group of 20 LTECs that lost viral and/or immunol. control during the follow-up study (LTEC-losing) and 9 EC patients with short-term viral and immunol. control (less than 5 years; no-LTEC patients). Long-term viral and immunol. HIV-1 control was found to be strongly associated with elevated tricarboxylic acid (TCA) cycle function. Interestingly, of the nine metabolites identified in the TCA cycle, α-ketoglutaric acid (p = 0.004), a metabolite implicated in the activation of the mTOR complex, a modulator of HIV latency and regulator of several biol. processes, was found to be a key metabolite in the persistent control. On the other hand, a lipidomics panel combining 45 lipid species showed an optimal percentage of separation and an ability to differentiate LTEC-extreme from LTEC-losing, revealing that an elevated lipidomics plasma profile could be a predictive factor for the reignition of viral replication in LTEC individuals. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Name: 2,3-Dihydroxypropanoic acid
The Article related to long term hiv control alpha ketoglutaric acid lipidomics metabolomics, hiv infection, kreb’s cycle, elite controllers (ecs), lipidomics, long-term, mass spectrometry, metabolomics, viral and other aspects.Name: 2,3-Dihydroxypropanoic acid
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