On April 30, 2022, Li, Kun-Ping; Yuan, Min; Wu, Yong-Lin; Pineda, Miguel; Zhang, Chu-Mei; Chen, Yan-Fen; Chen, Zhi-quan; Rong, Xiang-Lu; Turnbull, Jeremy E.; Guo, Jiao published an article.Synthetic Route of 473-81-4 The title of the article was A High-Fat High-Fructose Diet Dysregulates the Homeostatic Crosstalk Between Gut Microbiome, Metabolome, and Immunity in an Experimental Model of Obesity. And the article contained the following:
Ample evidence supports the prominent role of gut-liver axis in perpetuating pathol. networks of high-fat high-fructose (HFF) diet induced metabolic disorders, however, the mol. mechanisms are still not fully understood. Herein, this study aims to present a holistic delineation and scientific explanation for the crosstalk between the gut and liver, including the potential mediators involved in orchestrating the metabolic and immune systems. An exptl. obesity-associated metaflammation rat model is induced with a HFF diet. An integrative multi-omics anal. is then performed. Following the clues illustrated by the multi-omics discoveries, putative pathways are subsequently validated by RT-qPCR and Western blotting. HFF diet leads to obese phenotypes in rats, as well as histopathol. changes. Integrated omics anal. shows that there exists a strong interdependence among gut microbiota composition, intestinal metabolites, and innate immunity regulation in the liver. Some carboxylic acids may contribute to gut-liver communication. Moreover, activation of the hepatic LPS-TLR4 pathway in obesity is confirmed. HFF-intake disturbs gut flora homeostasis. Crosstalk between gut microbiota and innate immune system mediates hepatic metaflammation in obese rats, associated with LPS-TLR4 signaling pathway activation. Moreover, α-hydroxyisobutyric acid and some other organic acids may play a role as messengers in the liver-gut axis. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Synthetic Route of 473-81-4
The Article related to high fructose diet gut microbiome metabolome immunity obesity, lps-tlr4, chronic inflammation, gut microbiota, innate immune system, integrated multi-omics analysis, α-hydroxyisobutyric acid and other aspects.Synthetic Route of 473-81-4
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