Lee, Ji-Youn; Seo, Sumin; Shin, Bohyun; Hong, Se Hee; Kwon, Eunjin; Park, Sunwha; Hur, Young Min; Lee, Dong-Kyu; Kim, Young Ju; Han, Sang Beom published an article in 2022, the title of the article was Development of a New Biomarker Model for Predicting Preterm Birth in Cervicovaginal Fluid.Name: 2,3-Dihydroxypropanoic acid And the article contains the following content:
Preterm birth (PTB) is a social problem that adversely affects not only the survival rate of the fetus, but also the premature babies and families, so there is an urgent need to find accurate biomarkers. We noted that among causes, eubiosis of the vaginal microbial community to dysbiosis leads to changes in metabolite composition In this study, short chain fatty acids (SCFAs) representing dysbiosis were derivatized using (N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide, MTBSTFA) and targeted anal. was conducted in extracted organic phases of cervicovaginal fluid (CVF). In residual aqueous CVF, polar metabolites produced biochem. process were derivatized using methoxyamine and N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA), and non-targeted anal. were conducted. Nine SCFAs were quantified, and 58 polar metabolites were detected in 90 clin. samples using gas chromatog./mass spectrometry (GC/MS). The criteria of statistical anal. and detection rate of clin. sample for development of PTB biomarkers were presented, and 19 biomarkers were selected based on it, consisting of 1 SCFA, 2 organic acids, 4 amine compounds, and 12 amino acids. In addition, the model was evaluated as a suitable indicator for predicting PTB without distinction between sample collection time. We hope that the developed biomarkers based on microbiota-derived metabolites could provide useful diagnostic biomarkers for actual patients and pre-pregnancy. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Name: 2,3-Dihydroxypropanoic acid
The Article related to cervicovaginal fluid preterm birth biomarker model development, biomarker model, cervicovaginal fluid (cvf), polar metabolite, preterm birth (ptb), short chain fatty acid (scfa), vaginal microbiome and other aspects.Name: 2,3-Dihydroxypropanoic acid
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