On January 25, 2022, Heremans, Isaac P.; Caligiore, Francesco; Gerin, Isabelle; Bury, Marina; Lutz, Marilena; Graff, Julie; Stroobant, Vincent; Vertommen, Didier; Teleman, Aurelio A.; Van Schaftingen, Emile; Bommera, Guido T. published an article.Related Products of 473-81-4 The title of the article was Parkinson′s disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite. And the article contained the following:
Cells are continuously exposed to potentially dangerous compounds Progressive accumulation of damage is suspected to contribute to neurodegenerative diseases and aging, but the mol. identity of the damage remains largely unknown. Here we report that PARK7, an enzyme mutated in hereditary Parkinson′s disease, prevents damage of proteins and metabolites caused by a metabolite of glycolysis. We found that the glycolytic metabolite 1,3-bisphosphoglycerate (1,3-BPG) spontaneously forms a novel reactive intermediate that avidly reacts with amino groups. PARK7 acts by destroying this intermediate, thereby preventing the formation of proteins and metabolites with glycerate and phosphoglycerate modifications on amino groups. As a consequence, inactivation of PARK7 (or its orthologs) in human cell lines, mouse brain, and Drosophila melanogaster leads to the accumulation of these damaged compounds, most of which have not been described before. Our work demonstrates that PARK7 function represents a highly conserved strategy to prevent damage in cells that metabolize carbohydrates. This represents a fundamental link between metabolism and a type of cellular damage that might contribute to the development of Parkinson′s disease. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Related Products of 473-81-4
The Article related to park7 neuroprotectant metabolite protein cell damage glycolysis parkinson disease, parkinson’s disease, glycolysis, metabolite damage, posttranslational modification, protein damage and other aspects.Related Products of 473-81-4
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