On April 7, 2020, Grashow, Rachel; Bessonneau, Vincent; Gerona, Roy R.; Wang, Aolin; Trowbridge, Jessica; Lin, Thomas; Buren, Heather; Rudel, Ruthann A.; Morello-Frosch, Rachel published an article.Electric Literature of 96-76-4 The title of the article was Integrating Exposure Knowledge and Serum Suspect Screening as a New Approach to Biomonitoring: An Application in Firefighters and Office Workers. And the article contained the following:
Firefighters (FF) are exposed to recognized and probable carcinogens, yet there are few chem. exposure studies and associated health concerns for women firefighters, e.g., breast cancer. Biomonitoring often requires a-priori selection of compounds to be measured, and may not detect relevant, lesser known, exposures. The women firefighters biomonitoring collaborative (WFBC) created a biol. sample archive and conducted a general suspect screen (GSS) to address this data gap. Using liquid chromatog./quadrupole time-of-flight tandem mass spectrometry, candidate chems. of interest were identified in serum samples from 83 women (FF) and 79 women office workers (OW) in San Francisco, California. Chem. peaks were identified by matching accurate mass from serum samples to a custom chem. database of 722 slightly polar phenolic and acidic compounds, including many relevant to firefighting or breast cancer etiol. Collected tentatively identified chems. were selected for confirmation based on: detection frequency or peak area differences between OW and FF; evidence of mammary carcinogenicity, estrogenicity, or genotoxicity; and not currently measured in large biomonitoring studies. In total 620 chems. were detected which matched 300 mol. formulas in the WFBC database, including phthalate and phosphate flame retardant metabolites, phenols, pesticides, nitro- and nitroso-compounds, and per- and polyfluoroalkyl substances. Of 20 suspect chems. selected for validation, eight were confirmed (two alkylphenols, Et paraben, BPF, PFOSAA, benzophenone-3, benzyl p-hydroxybenzoate, tri-Ph phosphate) by running a matrix spike of reference standards and using m/z, retention time, and the confirmation of at least two fragment ions as matching criteria. GSS provided a powerful high-throughput approach to identify and prioritize novel chems. for biomonitoring and health studies. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Electric Literature of 96-76-4
The Article related to occupational health hazard women firefighter office worker chem exposure, risk assessment women firefighter office worker cancer chem exposure, carcinogen understudied compound biomonitoring women firefighter office worker and other aspects.Electric Literature of 96-76-4
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts