On December 31, 2020, Fagbohun, Oladapo F.; Olawoye, Babatunde; Ademakinwa, Adedeji N.; Jolayemi, Kehinde A.; Msagati, Titus A. M. published an article.Synthetic Route of 96-76-4 The title of the article was Metabolome modulatory effects of Kigelia africana (Lam.) Benth. fruit extracts on oxidative stress, hyperlipidaemic biomarkers in STZ-induced diabetic rats and antidiabetic effects in 3T3 L1 adipocytes. And the article contained the following:
The management of diabetes is considered a global problem, and a cure is yet to be discovered. This study investigated the modulatory effect of Kigelia africana fruit on oxidative stress and hyperlipidemic biomarkers in STZ-induced diabetic rats, profiled phytoconstituents using GC-TOF-MS and evaluated antidiabetic effects on 3T3 L1 adipocytes. Thirty male Wistar rats (120-150 g) were divided into six groups (n = 5). Diabetes was induced by a single i.p. injection of STZ (60 mg/kg) and treated with 100, 200 and 400 of hexane fraction of KA for 28 days. Immunohistochem. evaluation was carried out using avidin-biotin immunoperoxidase (ABI) method. Catalase and SOD activities as well as the levels of total protein, albumin, bilirubin, triglyceride, cholesterol, and high-d. lipoprotein were measured. The expressions of oxidative stress and hyperlipidemic biomarkers alongside fasting blood glucose concentrations were remarkedly decreased in KA-treated diabetic rats. Moreover, there was a significant increase in endocrine cell distribution, area covered with increase in β-cell mass, composition and morphol. of KA-treated animals. Addnl., there was constant up-regulation in 3T3 L1 adipocytes due to the presence of phytoconstituents. Kigelia africana fruit can act as a modulatory agent due to its ameliorative effects against oxidative stress. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Synthetic Route of 96-76-4
The Article related to metabolome modulatory effect kigelia africana oxidative stress hyperlipidemic biomarker, kigelia africana , diabetes mellitus , gc-tof-ms, antioxidant enzymes, avidin-biotin immunoperoxidase and other aspects.Synthetic Route of 96-76-4
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