On January 23, 2020, De Francesco, Raffaele; Donnici, Lorena; Guidotti, Luca; Iannacone, Matteo; Di Fabio, Romano; Summa, Vincenzo; Bencheva, Leda Ivanova; De Matteo, Marilenia; Ferrante, Luca; Prandi, Adolfo; Randazzo, Pietro published a patent.Electric Literature of 62640-03-3 The title of the patent was Preparation of arylaminocarbonyl bicyclic sulfonamides as inhibitors of hepatitis B virus. And the patent contained the following:
The invention relates to preparation of arylaminocarbonyl bicyclic sulfonamides (I) that are inhibitors of hepatitis B virus (HBV). Compounds I wherein B is a 6-membered aryl optionally containing one or more N atoms; X is N (un)substituted with R4, or is O; Y is a single bond, a double bond, C1-4 alkanediyl, etc.; Z is C(O) or CR2R3; R1 is H, OH, etc.; R2 is H, DNH2, etc.; R3 is absent, H, D, etc.; R4 is H, OH, C1-4 alkyl; R5 is C1-3 alkyl (un)substituted with OH; R6 is C1-4 alkyl; etc., are claimed. The example compound II was prepared from an intermediate (also prepared) and formaldehyde (procedure given). The compounds of the invention were evaluated for their biol. activity (data given). Compounds I are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The invention also relates to pharmaceutical compositions containing I. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Electric Literature of 62640-03-3
The Article related to arylaminocarbonyl bicyclic sulfonamide preparation antiviral hepatitis b combination therapy, hbv infection prophylaxis combination treatment arylaminocarbonyl bicyclic sulfonamide preparation and other aspects.Electric Literature of 62640-03-3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts