On January 15, 2009, Dalence, Maria; Johansson, Martin; Thornqvist Oltner, Viveca; Toftered, Joergen; Wensbo, David published a patent.Recommanded Product: (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was Preparation of novel bronchodilating isoquinoline carbamates. And the patent contained the following:
The title compounds I [R1, R2 = H or Me; R3, R4 = H, F, Cl, Br, alkyl, benzyl; G = (un)substituted alkylene(hetero)aryl; with the proviso that not both of R1 and R2 is Me; and the exclusion of 3 compounds], useful to manufacture a medicament to treat a disorder or disease characterized by bronchoconstriction, e.g. COPD and asthma, and by vasoconstriction, e.g. hypertension, were prepared E.g., a 3-step synthesis of I [R1, R2 = H; R3, R4 = Cl; G = CH2Ph], starting from 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, was given. Exemplified compounds I were tested for their biol. activity. For example, pre-treatment with I [R1, R2 = H; R3, R4 = Cl; G = CH2Ph] resulted in 38% remaining contraction of human bronchiols after leukotriene D4 (10 nM) induced contraction. Pharmaceutical composition comprising the compound I is disclosed. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Recommanded Product: (6-(Trifluoromethyl)pyridin-3-yl)methanol
The Article related to isoquinoline carbamate preparation bronchodilator bronchoconstriction vasoconstriction copd asthma hypertension, antiasthmatic antihypertensive isoquinoline carbamate preparation and other aspects.Recommanded Product: (6-(Trifluoromethyl)pyridin-3-yl)methanol
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