On December 31, 2013, Bolden, Sidney Jr.; Zhu, Xue Y.; Etukala, Jagan R.; Boateng, Comfort; Mazu, Tryphon; Flores-Rozas, Hernan; Jacob, Melissa R.; Khan, Shabana I.; Walker, Larry A.; Ablordeppey, Seth Y. published an article.SDS of cas: 72364-46-6 The title of the article was Structure-activity relationship (SAR) and preliminary mode of action studies of 3-substituted benzylthioquinolinium iodide as anti-opportunistic infection agents. And the article contained the following:
Opportunistic infections are devastating to immunocompromised patients. And in especially sub-Saharan Africa where the AIDS epidemic is still raging, the mortality rate was recently as high as 70%. The paucity of anti-opportunistic drugs, the decreasing efficacy and the development of resistance against the azoles and even amphotericin B have stimulated the search for new drugs with new mechanisms of action. In a previous work, we showed that a new chemotype derived from the natural product cryptolepine displayed selective toxicity against opportunistic pathogens with minimal cytotoxicity to normal cells. In this manuscript, we report the design and synthesis of substituted benzylthioquinolinium iodides, evaluated their anti-infective properties and formulated some initial structure-activity relationships around Ph ring A from the original natural product. The sensitivity of the most potent analog 10l, to selected strains of C. cerevisiae was also evaluated leading to the observation that this scaffold may have a different mode of action from its predecessor, cryptolepine. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).SDS of cas: 72364-46-6
The Article related to benzylthioquinolinium analog preparation sar antiinfective antifungal antibacterial, anti-opportunistic infections, antifungal agents, benzylthioquinolinium iodides, craig plot, cryptolepine, structure–activity relationships, substituted quinolinium salts and other aspects.SDS of cas: 72364-46-6
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