On July 31, 2022, Aydinli, Serdar Goksin; Bulut, Elif; Deniz, Nahide Gulsah; Sayil, Cigdem; Komarovska-Porokhnyavets, Olena; Lubenets, Vira; Zvarych, Viktor; Stasevych, Maryna; Nesterkina, Mariia; Kravchenko, Iryna published an article.Quality Control of 1-Decanethiol The title of the article was New Ketene Dithioacetals Generated from 2-Nitroperchlorobutadiene and Investigation of Their Antibacterial, Antifungal, Anticonvulsant and Antidepressant Activities. And the article contained the following:
The ketene dithioacetal 3 generated from 2-nitroperchlorobutadiene 1 reacted with various heterocyclic amines and aliphatic, aromatic and heterocyclic thiols to produce functionalized new ketene-N,S,S-acetals and S,S,S-acetals 4a-f, 5a-h as heterocyclic dithiolanes. They were separated/purified by chromatog. methods and their exact structure characterization were made clear by spectroscopic methods. These compounds synthesized could act as effective drugs for versatile activity. Evaluation of the antimicrobial effect of the obtained substances determined derivatives 4e and 5h, which have MIC=15.6 μg/mL for the test culture of Mycobacterium luteum bacteria closing to the control drug Vancomycin. The obtained compounds can be proposed as a promising synthetic objects for future mol. design to enhance the antimicrobial action. Ketene dithioacetals 3, 4a, 4b, 4e, 5g (50 mg/kg) exhibited antiseizure effect comparable with reference drug (valproic acid) on the model of pentylenetetrazole-induced convulsions after single oral administration both at 3 h and 24 h. Furthermore, tested dithioacetals possessed prolonged antidepressant activity in forced swim test (FST) considerable decreasing the duration of immobility time compared to reference drug amitriptyline. This is the first study of the investigation of anticonvulsant and antidepressant activities of ketene dithioacetals. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Quality Control of 1-Decanethiol
The Article related to ketene dithioacetals nitroperchlorobutadiene antibacterial antifungal anticonvulsant antidepressant activity, antibacterial activity, anticonvulsant action, antidepressant effect, antifungal activity, ketene dithioacetal and other aspects.Quality Control of 1-Decanethiol
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