Month: October 2022

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 533-73-3, formula is C6H6O3, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Electric Literature of 533-73-3

Yang, Li;Zhang, Qi;Han, Ying;Li, Hongjuan;Sun, Shiguo;Xu, Yongqian research published 《 The selective deprotonation of carbon quantum dots for fluorescence detection of phosphate and visualization of latent fingerprints》, the research content is summarized as follows. We developed a water-soluble, stable and selective “turn-on” fluorescence sensing platform based on carbon quantum dots (CQDs) for rapid determination of phosphate (Pi) in aqueous solutions and for visualization of latent fingerprints on paper. The hydroxyl groups on the surface of the synthesized CQDs can be deprotonated by Pi to trigger the intramol. charge transfer (ICT) process and the inhibition of excited-state proton transfer (ESPT), achieving a turn-on emission response. CQDs demonstrated the capability to selectively detect Pi over other common ions and biomols. with the linear fluorescence intensity change in the range from 0 to 100μM. Moreover, the paper sprayed with the CQD solution showed a remarkable blue emission speckle and a fingerprint upon addition of Pi solution and finger touching, resp. Notably, the fingerprint images including level 3 details (crossover, bifurcation, termination, and island and sweat pores) are also clearly identified and distinguished, indicating their potential application in document security. We believe that the as-synthesized CQDs will provide a new tool for Pi detection in aqueous media and paper document security.

Electric Literature of 533-73-3, Benzene-1, 2, 4-triol, also known as hydroxyhydroquinone or 1, 2, 4-benzenetriol, belongs to the class of organic compounds known as hydroxyquinols and derivatives. Hydroxyquinols and derivatives are compounds containing a 1, 2, 4-trihydroxybenzene moiety. Benzene-1, 2, 4-triol is soluble (in water) and a very weakly acidic compound (based on its pKa). Outside of the human body, benzene-1, 2, 4-triol can be found in tea. This makes benzene-1, 2, 4-triol a potential biomarker for the consumption of this food product.
Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4. It has a role as a mouse metabolite.
1,2,4-Benzenetriol is a metabolite of benzene.
1,2,4-Benzenetriol is an intermediary metabolite of benzene that is present in roasted coffee beans. It is mutagenic and it causes cleaving of DNA single strands by the generation of reactive oxygen species.
1,2,4-Benzenetriol is a reactive molecule that has been shown to have hydrogen bonding interactions with copper chloride. It has been proposed as an inhibitor of methyltransferase, which is involved in the synthesis of methionine. Studies have shown that 1,2,4-Benzenetriol can also inhibit iron homeostasis and transfer reactions. The x-ray diffraction data for this compound shows that it forms a complex with the hydroxyl group. This complex is stabilized by hydrogen bonding interactions with the hydroxylic proton of the 1,2,4-benzenetriol molecule. 1,2,4-Benzenetriol has been shown to be toxic to HL-60 cells and K562 cells at concentrations greater than 5 mM. It has also been found to be effective against chlorogenic acids and other compounds in energy metabolism studies at concentrations between 0.5 and 2 mM., 533-73-3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 16545-68-9, formula is C3H6O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Reference of 16545-68-9

Yang, Gan;Huo, Juntao;Wang, Lihong;Wang, Yuwei;Wu, Shijian;Yao, Lei;Fu, Qingyan;Wang, Lin research published 《 Total OH Reactivity Measurements in a Suburban Site of Shanghai》, the research content is summarized as follows. Total hydroxyl radicals (OH) reactivity, as a measure of the OH total loss rate and the significance of atm. oxidation, is broadly used to evaluate the OH budget in the atm. Here, measurements of the total OH reactivity were performed at a suburban air quality monitoring supersite (Dianshan Lake) of Shanghai, between 1 August and 15 Sept., 2020, using the Comparative Reactivity Method. The measured total OH reactivity ranged from 13.9 to 107.4 s^-1 with an average of 38.4 s^-1. Meanwhile, the calculated total OH reactivity varied between 8.9 and 84.4 s^-1 from concentrations of atm. trace gases measured by multiple in-situ techniques including an online gas chromatograph equipped with mass spectrometry and flame ionization detection (GC-MS/FID) and two proton-transfer-reaction time-of-flight mass spectrometers (PTR-ToF-MSs). A 12.1missing OH reactivity was evident from the comparison between the measured and calculated total OH reactivities. Inorganic trace gases, methane, and 54 observed Photochem. Assessment Monitoring Station compounds detected by GC-MS/FID, accounted for 25.7, 1.3, and 10, resp., of the calculated total OH reactivity. In addition, 292 species detected by PTR-ToF-MSs contributed the rest 63. The top 10 VOC contributors to the measured total OH reactivity were C₅H₈, CH₂O, C₂H₄O, C₆H₆O, C₄H₈O, C₃H₆O, C₁₀H₁₆, C₅H₁₀O, C₅H₈O₂, and C₈H₁₀, resp., whose total contribution reached 42. Correlation anal. for the missing OH reactivity suggests that primary biogenic VOCs could be a potential source for the missing OH reactivity during the daytime, and that secondary oxidation products might also be connected to the missing OH reactivity.

16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., Reference of 16545-68-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 16545-68-9, formula is C3H6O, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. Reference of 16545-68-9

Yang, Chaofu;Wang, Jing;Cheng, Yunyun;Yang, Xu;Feng, Yan;Zhuang, Xiaomei;Li, Zhenwang;Zhao, Wangyu;Zhang, Jiwen;Sun, Xianyu;He, Xinhua research published 《 N-Quinary heterocycle-4-sulphamoylbenzamides exert anti-hypoxic effects as dual inhibitors of carbonic anhydrases I/II》, the research content is summarized as follows. Acute mountain sickness (AMS) affects approx. 25-50% of newcomers to high altitudes. Two human carbonic anhydrase isoforms, hCA I and II, play key roles in developing high altitude illnesses. However, the only FDA-approved drug for AMS is acetazolamide (AAZ), which has a nearly 100 times weaker inhibitory activity against hCA I (K_i = 1237.10 nM) than hCA II (K_i = 13.22 nM). Hence, developing potent dual hCA I/II inhibitors for AMS prevention and treatment is a critical medical need. Here we identified N-quinary heterocycle-4-sulphamoylbenzamides as potent hCA I/II inhibitors. The newly designed compounds 2b, 5b, 5f, 6d, and 6f possessed the desired inhibitory activities (hCA I: Ki = 16.95-52.71 nM; hCA II: K_i = 8.61-18.64 nM). Their hCA I inhibitory capacity was 22- to 76-fold stronger than that of AAZ. Relative to the control group for survival in a mouse model of hypoxia, 2b and 6d prolonged the survival time of mice by 21.7% and 29.3%, resp., which was longer than those of AAZ (6.5%). These compounds did not display any apparent toxicity in vitro and in vivo. In addition, docking simulations suggested that the quinary aromatic heterocycle groups stabilized the interaction between hCA I/II and the inhibitors, which could be further exploited in structure optimization studies. Hence, future functional studies may confirm 2b(I) and 6d(II) as potential clin. candidate compounds with anti-hypoxic activity against AMS.

Reference of 16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 72824-04-5, formula is C9H17BO2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Reference of 72824-04-5

Yang, Chao;Gao, Yadong;Bai, Songlin;Jiang, Chao;Qi, Xiangbing research published 《 Chemoselective Cross-Coupling of gem-Borazirconocene Alkanes with Aryl Halides》, the research content is summarized as follows. The direct and chemoselective conversion of the C-metal bond of gem-dimetallic reagents enables rapid and sequential formation of multiple C-C and C-heteroatom bonds, thus representing a powerful method for efficiently increasing structural complexity. Herein, the authors report a visible-light-induced, Ni-catalyzed, chemoselective cross-coupling reaction between gem-borazirconocene alkanes and diverse aryl halides, affording a wide range of alkyl Bpin derivatives in high yields with excellent regioselectivity. This practical method features attractively simple reaction conditions and a broad substrate scope. Addnl., the authors systematically studied a Bpin-directed chain walking process underlying the regioselectivity of alkylzirconocenes, thus uncovering the mechanism of the remote functionalization of internal olefins achieved with the authors’ method. Finally, DFT calculations indicate that the high regioselectivity of this reaction originates from the directing effect of the Bpin group.

72824-04-5, Allylboronic acid pinacol ester is a useful research compound. Its molecular formula is C9H17BO2 and its molecular weight is 168.04 g/mol. The purity is usually 95%.
Allylboronic acid pinacol ester is an allylation reagent that is used to produce aldehydes from ketones. It reacts with water, yielding the desired product and formaldehyde as a byproduct. The reaction proceeds through a sequence of steps, in which the boronate ester first reacts with water to form an allylboronate ion and hydrogen gas. This intermediate then reacts with potassium t-butoxide to produce the desired allyl alcohol and potassium borohydride. Finally, the palladium complex catalyst reduces the carbonyl group of the starting material, converting it into an aldehyde. Allylboronic acid pinacol ester is commercially available as a white solid, but can also be synthesized from 2-chloro-5-pinacolylborane (pinacol) in high yield using catalytic cross coupling reactions., Reference of 72824-04-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 533-73-3, formula is C6H6O3, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Product Details of C6H6O3

Yan, Zhifeng;Lian, Jie;Feng, Yu;Li, Miaoting;Long, Feng;Cheng, Ruoqian;Shi, Sheng;Guo, Hong;Lu, Jianjun research published 《 A mechanistic insight into glucose conversion in subcritical water: Complex reaction network and the effects of acid-base catalysis》, the research content is summarized as follows. Based on the concept of system thinking and system design, a systematically mechanistic network of glucose conversion toward fructose, 5-hydroxymethyl furfural, 1,6-anhydroglucose, 1,2,4-Benzenetriol, levulinic acid, furfural, erythrose, glyceraldehyde, dihydroxyacetone, pyruvaldehyde, lactic acid, glycolaldehyde in subcritical water were performed by employing dispersion-corrected d. functional theory. Fukui functions results predict the most highest reactivity of O(5) of glucose to suffer protonation in subcritical water, which may readily lead to the formation of 1,6-anhydroglucose or fructose with the comparable apparent activation energies (29.441 vs 29.305 kcal/mol). Further dehydration of monosaccharide to 5-HMF is more favorable via cyclic pathway for fructose in comparison to the acyclic pathway for glucose. The formation of levulinic acid has an apparent activation energy of 33.321 kcal/mol but the rate is limited by the numerous steps. The consumption of 5-HMF to 1,2,4-Benzenetriol exhibits a high activation energy of 76.682 kcal/mol. Retro-aldol condensation of C4 compounds prefer to give C2 rather than C3 compounds The thermodn. results involving the generation of C2, C3 and C4 compounds by retro-aldol condensation of open-chain C6 intermediates agree with the exptl. product distribution and reactivity over temperature at the initial stage of glucose or fructose subcritical hydrolysis. Furthermore, the assistance of H+ may be responsible for the isomerization and retro-aldol condensation in glucose conversion. This comprehensive reaction network provides a fundamental understanding and deeper insight into glucose conversion, which reasonably explains exptl. activity and selectivity reported for glucose and fructose conversion in subcritical water.

Product Details of C6H6O3, Benzene-1, 2, 4-triol, also known as hydroxyhydroquinone or 1, 2, 4-benzenetriol, belongs to the class of organic compounds known as hydroxyquinols and derivatives. Hydroxyquinols and derivatives are compounds containing a 1, 2, 4-trihydroxybenzene moiety. Benzene-1, 2, 4-triol is soluble (in water) and a very weakly acidic compound (based on its pKa). Outside of the human body, benzene-1, 2, 4-triol can be found in tea. This makes benzene-1, 2, 4-triol a potential biomarker for the consumption of this food product.
Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4. It has a role as a mouse metabolite.
1,2,4-Benzenetriol is a metabolite of benzene.
1,2,4-Benzenetriol is an intermediary metabolite of benzene that is present in roasted coffee beans. It is mutagenic and it causes cleaving of DNA single strands by the generation of reactive oxygen species.
1,2,4-Benzenetriol is a reactive molecule that has been shown to have hydrogen bonding interactions with copper chloride. It has been proposed as an inhibitor of methyltransferase, which is involved in the synthesis of methionine. Studies have shown that 1,2,4-Benzenetriol can also inhibit iron homeostasis and transfer reactions. The x-ray diffraction data for this compound shows that it forms a complex with the hydroxyl group. This complex is stabilized by hydrogen bonding interactions with the hydroxylic proton of the 1,2,4-benzenetriol molecule. 1,2,4-Benzenetriol has been shown to be toxic to HL-60 cells and K562 cells at concentrations greater than 5 mM. It has also been found to be effective against chlorogenic acids and other compounds in energy metabolism studies at concentrations between 0.5 and 2 mM., 533-73-3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 527-07-1, formula is C6H11NaO7, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. Formula: C6H11NaO7

Yan, Yu;Wang, Rui;Wang, Wenbin;Yu, Cheng;Liu, Jiaping research published 《 Effect of starch-based admixtures on the exothermic process of cement hydration》, the research content is summarized as follows. The effect of three types of starch-based admixtures, namely glucose and its derivatives, soluble dextrin with various d.p. and a novel starch-based temperature rise inhibitor (TRI) with various degree of starch acidification on the exothermic process of cement hydration has been investigated through the calorimetry measurements. Except delaying the appearance of the main hydration peak as the retarding effect, starch-based admixtures can also reduce the heat flow during the acceleration period and induce a lower maximum heat flow as the depressing effect. Together with the dissolution and adsorption results, it can be concluded that the relationship between these two effects is determined by the action time of mol. in the cement paste. The soluble admixtures with fairly short action time focus mainly on disturbing the cement hydration during the induction period but have minor effect on depressing the main hydration peak. TRI with limited dissolution can persistently inhibit the cement hydration over a longer period of action time, inducing negligible retarding effect but apparent depressing effect.

Formula: C6H11NaO7, Sodium Gluconate is the sodium salt of gluconic acid with chelating property. Sodium gluconate chelates and forms stable complexes with various ions, preventing them from engaging in chemical reactions.
Sodium gluconate is an organic sodium salt having D-gluconate as the counterion. It has a role as a chelator. It contains a D-gluconate.
D-Gluconic acid sodium salt is a glycol ether that is used as an injection solution. It has been shown to have antibacterial efficacy against wild-type strains of bacteria such as Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The in vitro antimicrobial action of D-gluconic acid sodium salt was found to be due to its ability to inhibit bacterial growth by interfering with the synthesis of DNA. D-gluconic acid sodium salt also has been shown to have antihypertensive effects in rats through the inhibition of angiotensin II type 1 receptor (AT1) signaling pathway and erythrocyte proliferation. This drug also has been shown to bind benzalkonium chloride and x-ray diffraction data show that it is crystalline in nature. The analytical method for determining the concentration of D-gluconic acid sodium salt is by electrochemical impedance, 527-07-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 7748-36-9, formula is C3H6O2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Reference of 7748-36-9

Yan, Xingxiu;Wang, Shengchun;Liu, Zhao;Luo, Yujie;Wang, Pengjie;Shi, Wenyan;Qi, Xiaotian;Huang, Zhiliang;Lei, Aiwen research published 《 Precise electro-reduction of alkyl halides for radical defluorinative alkylation》, the research content is summarized as follows. A precise electro-reduction strategy for radical defluorinative alkylation towards the synthesis of gem-difluoroalkenes from α-trifluoromethylstyrenes was reported. According to the redox-p.d. of the radical precursors, direct or indirect electrolysis was resp. adopted to realize the precise reduction An easy-to-handle, catalyst- and metal-free condition was developed for the reduction of alkyl radical precursors that are generally easier to be reduced than α-trifluoromethylstyrenes, while a novel electro-Ni-catalytic system was established for the electro-reduction of alkyl bromides or chlorides towards the electrochem. synthesis of gem-difluoroalkenes. The merit of this protocol was exhibited by its mild conditions, wide substrate scope, and scalable preparation Mechanistic studies and DFT calculations proved that the coordination of α-trifluoromethylstyrenes to Ni-catalyst prevents the direct reduction of the alkene and, in turn, promotes the activation of alkyl bromide through halogen atom transfer mechanism.

Reference of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 141699-55-0, formula is C8H15NO3, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Electric Literature of 141699-55-0

Yan, Xingxiu;Wang, Shengchun;Liu, Zhao;Luo, Yujie;Wang, Pengjie;Shi, Wenyan;Qi, Xiaotian;Huang, Zhiliang;Lei, Aiwen research published 《 Precise electro-reduction of alkyl halides for radical defluorinative alkylation》, the research content is summarized as follows. A precise electro-reduction strategy for radical defluorinative alkylation towards the synthesis of gem-difluoroalkenes from α-trifluoromethylstyrenes was reported. According to the redox-p.d. of the radical precursors, direct or indirect electrolysis was resp. adopted to realize the precise reduction An easy-to-handle, catalyst- and metal-free condition was developed for the reduction of alkyl radical precursors that are generally easier to be reduced than α-trifluoromethylstyrenes, while a novel electro-Ni-catalytic system was established for the electro-reduction of alkyl bromides or chlorides towards the electrochem. synthesis of gem-difluoroalkenes. The merit of this protocol was exhibited by its mild conditions, wide substrate scope, and scalable preparation Mechanistic studies and DFT calculations proved that the coordination of α-trifluoromethylstyrenes to Ni-catalyst prevents the direct reduction of the alkene and, in turn, promotes the activation of alkyl bromide through halogen atom transfer mechanism.

Electric Literature of 141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 141699-55-0, formula is C8H15NO3, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. HPLC of Formula: 141699-55-0

Yan, Qi;Wang, Yujie;Zhang, Wei;Li, Yingxia research published 《 Novel azetidine-containing TZT-1027 analogues as antitumor agents》, the research content is summarized as follows. A conformational restriction strategy was used to design and synthesize nine TZT-1027 analogs. 3-Aryl-azetidine moiety was used to replace phenylethyl group of TZT-1027 at the C-terminus. These analogs exhibited moderate to excellent antiproliferative activities, and the most potent compound 1a showed IC50 values of 2.2 nM against A549 and 2.1 nM against HCT116 cell lines, resp. However, 1a could not achieve effective inhibition at all the dose levels in the A549 xenograft model (up to 5 mg/kg, injection, once a day), which is only 16%-35% inhibition at the end of the experiment

141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., HPLC of Formula: 141699-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 141699-55-0, formula is C8H15NO3, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. Electric Literature of 141699-55-0

Yan, Hao;Li, Xincheng;Wang, Chunxiang;Wan, Boshun research published 《 Silver-catalyzed cyclization of nitrones with 2-azetine: a radical approach to 2,3-disubstituted quinolines》, the research content is summarized as follows. A silver-catalyzed intermol. tandem cyclization of nitrones with 2-azetine was developed for the synthesis of 2,3-disubstituted quinolines I (R = H, 8-MeO, 6-Cl, etc.; Ar = Ph, 4-FC₆H₄, 4-MeOC₆H₄, etc.) under mild conditions with good yields. This approach features a C-N bond cleavage of 2-azetine and an N-O bond cleavage of nitrones via a radical pathway. The results of this study provide a new reaction pattern for nitrones and may find applications in the synthesis of other heterocycles.

Electric Literature of 141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts