Month: October 2022

Recommanded Product: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochlorideIn 1975, Yamashita, Junko published 《Action site of antagonists of vitamin B6 in the central nervous system of frogs and cockroaches》. 《Journal of Nutritional Science and Vitaminology》published the findings. The article contains the following contents:

Treatment with thiosemicarbazide [79-19-6], semicarbazide-HCl [563-41-7], isoniazide [54-85-3], DL-penicillamine [52-66-4], or toxopyrimidine [73-67-6] induced wild leaping or jumping behavior, and tonic or clonic convulsions in the frog (Rana nigromaculata) in which the nervous parts posterior to the optic lobe inclusive remained intact. No convulsions were induced by castrix [535-89-7] or 4-deoxypyridoxine-HCl [148-51-6] in frogs in which the nervous parts anterior to the diencephalon inclusive had been removed. Excessive restlessness and convulsions were induced by thiosemicarbazide in cockroaches (Periplaneta americana) in which the central nerve cord was severed between the subesophageal and prothoracic ganglia. To complete the study, the researchers used 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Recommanded Product: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

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Yasui, Masamichi;Hanaya, Kengo;Sugai, Takeshi;Higashibayashi, Shuhei published 《Metal-free thermal organocatalytic pinacol coupling of arylaldehydes using an isonicotinate catalyst with bis(pinacolato)diboron》 in 2021. The article was appeared in 《RSC Advances》. They have made some progress in their research.Related Products of 579-43-1 The article mentions the following:

The metal-free thermal organocatalytic pinacol coupling of arylaldehydes has been developed. The intermol. coupling of arylaldehydes catalyzed by t-Bu isonicotinate with bis(pinacolato)diboron as the co-reducing agent afforded 1,2-diphenylethane-1,2-diols. This reaction was also applicable to the intramol. coupling of 1,1′-biphenyl-2,2′-dicarbaldehydes to afford 9,10-dihydrophenanthrene-9,10-diols. Various functional groups were tolerated under this coupling condition.rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) were involved in the experimental procedure.

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Related Products of 579-43-1) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Das, Mitali;Shu, Chi-Min published 《A green approach towards adoption of chemical reaction model on 2,5-dimethyl-2,5-di-(tert-butylperoxy)hexane decomposition by differential isoconversional kinetic analysis》 in 2016. The article was appeared in 《Journal of Hazardous Materials》. They have made some progress in their research.Category: alcohols-buliding-blocks The article mentions the following:

This study studied the thermal degradation products of 2,5-dimethyl-2,5-di-(tert-butylperoxy) hexane (DBPH), by TG/GC/MS to identify runaway reaction and thermal safety parameters. It also included the determination of time to maximum rate under adiabatic conditions (TMR_ad) and self-accelerating decomposition temperature obtained through Advanced Kinetics and Technol. Solutions The apparent activation energy (E_a) was calculated from differential isoconversional kinetic anal. method using DSC experiments The E_a value obtained by Friedman anal. is at 118.0-149.0 kJ mol^-1. The TMR_ad was 24.0 h with an apparent onset temperature of 82.4°. This study also established an efficient benchmark for a thermal hazard assessment of DBPH that can be applied to assure safer storage conditions.2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) were involved in the experimental procedure.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) is used as an intermediate in the preparation of 2.5-Dimethyl-2.5-bis(tertbutyl-peroxy)hexane. It is also used in the synthesis of six- and seven-membered heterocyclic boron compounds.Category: alcohols-buliding-blocks

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Today I want to share an article with you. The article is 《Performance evaluation of ceramic membrane bioreactor: effect of operational parameters on micropollutant removal and membrane fouling》,you can find this article in 《Environmental Science and Pollution Research》. The following contents are mentioned:

This paper presents the removal of nine potential endocrine disruptors including pesticides, pharmaceuticals and industrial chems. using a submerged membrane bioreactor (MBR) system. Two lab-scale submerged MBRs having ceramic membranes were operated at three different sludge retention times (SRT: 15, 45, 90 days) and two hydraulic retention times (HRT: 12, 6 h) and the effects of SRT and HRT on both micropollutant removal and membrane fouling were investigated. While the effect of SRT and HRT change was observed on the removal of atrazine, fluoxetine, penconazole, no significant change was detected for the other micropollutants studied. It was determined that physicochem. properties such as distribution coefficient (LogD) and hydrophobicity of micropollutants are also effective on the removal efficiency of micropollutants. High removal efficiencies (≥ 97.5%) were observed for hydrophobic pollutants (logD > 3.2) except for penconazole (72.1%) and for hydrophilic pollutants (logD < 3.2) except for atrazine (42.5%). Membrane fouling was significantly affected by different operational parameters applied, with the slowest fouling occurring at 45 days of SRT and 12 h of HRT. However, micropollutant addition did not have a significant effect on membrane fouling. It has been shown that the simultaneous and effective treatment performance for micropollutants makes the membrane bioreactor system a promising wastewater treatment process. To complete the study, the researchers used 4-tert-Octylphenol (cas: 140-66-9) .

4-tert-Octylphenol(cas: 140-66-9) is a common environmental pollutant showing weak estrogenic effects.Application In Synthesis of 4-tert-Octylphenol It has been shown to cause harm to vertebrate male reproductive systems.

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Reference of 2-Hexyl-1-decanol《Characterization of the physicochemical changes and volatile compound fingerprinting during the chicken sugar-smoking process》 was published in 2021. The authors were Chang, Hong;Wang, Ying;Xia, Qiang;Pan, Daodong;He, Jun;Zhang, Haimeng;Cao, Jinxuan, and the article was included in《Poultry Science》. The author mentioned the following in the article:

Sugar-smoking contributes to improving flavor attributes of meat products. However, there is rather limited information concerning the relationship between sugar-smoking process parameters and volatile compound (VC) fingerprinting as well as related quality attributes of sugar-smoked chicken. In this work, the changes in VC across the whole sugar-smoking process were determined and analyzed and physicochem. properties, free fatty acid, thiobarbituric acid reactive substances values, and E-nose were also performed to characterize the quality properties of sugar-smoked chicken breast (CB) and chicken skin (CS). Results suggested that a higher amount (P < 0.05) of total VC was observed in CS compared with CB during the whole processing, which may be correlated with higher thiobarbituric acid reactive substances values, and higher polyunsaturated fatty acid/saturated fatty acid ratio. According to E-nose anal., the volatile flavor is clearly separated in the sugar-smoking stage. Volatile fingerprinting results revealed that heterocycles were the characteristic flavor formed during sugar-smoking process and hexanal, nonanal, furfural, 5-methyl-2-furancarboxaldehyde, and 2-acetyl-5-methylfuran were the major volatiles of the CS, which was closely related to lipid oxidation and caramelization reaction. Above all, the flavor of sugar-smoked chicken was mainly derived from CS and sugar-smoked process improved the flavor of CS. This study could provide theor. guidance for regulation of the color and flavor of sugar-smoked chicken and further promote the development of the industry. And 2-Hexyl-1-decanol (cas: 2425-77-6) was used in the research process.

2-Hexyl-1-decanol(cas: 2425-77-6) is a branched alcohol. It is one of the constituent of the essential oil, extracted from the roots of Adiantum flabellulatum. Reference of 2-Hexyl-1-decanol

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Meldrum, B. S. published 《Convulsive effects of 4-deoxypyridoxine in photosensitive baboons》 in 1971. The article was appeared in 《British Journal of Pharmacology》. They have made some progress in their research.Synthetic Route of C8H12ClNO2 The article mentions the following:

In baboons (Papio papio) which when exposed to intermittent light stimulation (ILS) showed myoclonus and electroencephalographic signs of epilepsy, deoxypyridoxine-HCl (I) (10-20 mg/kg, i.v.) did not modify the responses, while 15 min-2 hr after 40-60 mg I/kg, the myoclonic responses to ILS were enhanced. Animals normally giving transient myoclonic responses showed rhythmic myoclonus of the eyelids and face continuing for several sec after the end of ILS. In 4 out of 6 baboons after 80-100 mg I/kg this self-sustaining myoclonus developed into a full tonic-clonic seizure at least once 45-180 min after the drug injection. The injection of 105-150 mg I/kg not only enhanced myoclonic responses to ILS but also led to the appearance after 46-67 min of spontaneous seizures. These recurred every 10-15 min, were often only partial, and commonly originated in, and were sometimes confined to, the occipital cortex. An excess of pyridoxine, given i.v. a few minutes before and after the I, blocked both the enhancement of photosensitivity produced by 100 mg I/kg and spontaneous seizures produced by 150 mg/kg. I may produce these convulsive effects by interfering with the formation or action of pyridoxal phosphate. And 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) was used in the research process.

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Synthetic Route of C8H12ClNO2) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

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Name: 2,2-Methylenebis(6-tert-butyl-p-cresol)《Effects of Lactobacillus plantarum and Saccharomyces cerevisiae co-fermentation on the structure and flavor of wheat noodles》 was published in 2022. The authors were Ge, Zhenzhen;Wang, Weijing;Xu, Mingyue;Gao, Shanshan;Zhao, Yuxiang;Wei, Xiaopeng;Zhao, Guangyuan;Zong, Wei, and the article was included in《Journal of the Science of Food and Agriculture》. The author mentioned the following in the article:

Although traditional fermented noodles possess high eating quality, it is difficult to realize large-scale industrialization as a result of the complexity of spontaneous fermentation In present study, com. Lactobacillus plantarum and Saccharomyces cerevisiae were applied in the preparation of fermented noodles. The changes in the structural characteristics and aroma components of noodles after fermentation were investigated via SEM (SEM), Fourier transform IR spectroscopy (FTIR), low-field magenetic resonance imaging, electronic nose, and simultaneous distillation and extraction/gas chromatog.-mass spectrometry (GC-MS) anal. SEM images revealed that co-fermentation of the L. plantarum and S. cerevisiae for 10-40 min enhanced the continuity of the gluten network and promoted the formation of pores. FTIR spectra anal. showed that the co-fermentation increased significantly (P < 0.05) the proportion of α-helixes of noodles gluten protein, enhancing the orderliness of the mol. structure of protein. After fermentation for 10-40 min, the signal d. of hydrogen protons increased from the surface to the core, indicating that the water in the noodles migrated inward during a short fermentation process. The results of multivariate statistical anal. demonstrated that the main aroma differences between unfermented and fermented noodles were mainly in hydrocarbons, aromatic compounds and inorganic sulfides. GC-MS anal. indicated that the main volatile compounds detected were 2, 4-di-tert-butylphenol, bis (2-ethylhexyl) adipate, Bu acetate, di-Bu phthalate, dioctyl terephthalate, bis (2-ethylhexyl) phthalate, pentanol and 2-pentylfuran, etc. Co-fermentation with L. plantarum and S. cerevisiae improved the structure of gluten network and imparted more desirable volatile components to wheat noodles. 2022 Society of Chem. Industry. The experimental procedure involved many compounds, such as 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Name: 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Name: 2,5-Dimethyl-2,5-hexanediol《The synthesis of lactone-bridged 1,3,5-triphenylbenzene derivatives as pi-expanded coumarin triskelions》 was published in 2017. The authors were Hintz, Heather A.;Sortedahl, Nicholas J.;Meyer, Samantha M.;Decato, Daniel A.;Dahl, Bart J., and the article was included in《Tetrahedron Letters》. The author mentioned the following in the article:

Two triply lactone-bridged 1,3,5-triphenylbenzene derivatives I and II with solubilizing moieties were synthesized in five and six steps from com. available starting materials. Compounds containing the 1,3,5-triphenylbenzene core with two atom bridges are relatively unknown. This new class of pi-expanded coumarins contain triskelion architectures and X-ray crystallog. studies of one of the triskelions indicated that the 1,3,5-triphenylbenzene core adopted a near-planar geometry. This is the only known example of a two atom-bridged 1,3,5-triphenylbenzene derivative to adopted a planar structure.2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) were involved in the experimental procedure.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) is used as an intermediate in the preparation of 2.5-Dimethyl-2.5-bis(tertbutyl-peroxy)hexane. It is also used in the synthesis of six- and seven-membered heterocyclic boron compounds.Name: 2,5-Dimethyl-2,5-hexanediol

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Yang, Hyeri;Kim, Da-eun;Jang, Won-Hee;An, Susun;Cho, Sun-A.;Jung, Mi-Sook;Lee, Ji Eun;Yeo, Kyung-Wook;Koh, Sang Bum;Jeong, Tae-Cheon;Kang, Mi-Jeong;Chun, Young-Jin;Lee, Su-Hyon;Lim, Kyung-Min;Bae, SeungJin published 《Prevalidation trial for a novel in vitro eye irritation test using the reconstructed human cornea-like epithelial model, MCTT HCE》 in 2017. The article was appeared in 《Toxicology In Vitro》. They have made some progress in their research.SDS of cas: 110-03-2 The article mentions the following:

Here, the authors report the results of a prevalidation trial for an in vitro eye irritation test (EIT) using the reconstructed human cornea-like epithelium, MCTT HCE. The optimal cutoff to determine irritation in the prediction model was established at 35% with the receiver operation characteristics(ROC) curve for 126 substances. Within-lab(WL) and between-lab(BL) reproducibility was tested for 20 reference substances by 3 participating laboratories Viability data described by mean or ± 1/2 difference between duplicate wells, and scatter plots, demonstrated the WL/BL consistency. WL/BL concordance with the binary decision, whether non-irritant or irritant was estimated to be 85-95% and 95%, resp. WL/BL reproducibility of viability data was further supported by a strong correlation(ICC, r >0.9). WL/BL agreement of binary decisions was also examined by Fleiss’ Kappa statistics, which showed a strong level of agreement (>0.78), nevertheless weaker than the reproducibility of the viability. The EIT with MCTT HCE exhibited a sensitivity of 82.2% (60/73), a specificity of 81.1% (43/53), and an accuracy of 81.8% (103/126) for 126 reference substances (for liquids; a sensitivity of 100% (47/47), a specificity of 70.6% (24/34), and an accuracy of 87.7% (71/81), and for solids, a sensitivity of 50% (13/26), a specificity of 100% (19/19), and an accuracy of 71.1% (32/45)), suggesting that the accuracy is satisfactory but the sensitivity needs improvement, which shall be addressed through correcting the poor sensitivity for solid substances in future full validation trials. And 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) was used in the research process.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) was used in the synthesis of six- and seven-membered heterocyclic boron compounds containing intramolecular N-B bond.SDS of cas: 110-03-2

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Name: 4-(2-Phenylpropan-2-yl)phenolIn 2021, Yue, Wenlong;Yin, Chao-Fan;Sun, Limin;Zhang, Jie;Xu, Ying;Zhou, Ning-Yi published 《Biodegradation of bisphenol-A polycarbonate plastic by Pseudoxanthomonas sp. strain NyZ600》. 《Journal of Hazardous Materials》published the findings. The article contains the following contents:

Bisphenol-A polycarbonate (PC) is a widely used engineering thermoplastic and its release has caused damage to the ecosystem. Microbial degradation of plastic represents a sustainable approach for PC reduction In this study, a bacterial strain designated Pseudoxanthomonas sp. strain NyZ600 capable of degrading PC was isolated from activated sludge by using di-Ph carbonate as a surrogate substrate. Within a 30-day period of incubating with strain NyZ600, PC films were analyzed with at. force microscopy, scanning electron microscope, water contact angle, XPS, fourier transform IR spectroscopy, differential scan calorimeter and thermogravimetric anal. technique. The analyses results indicated that the treated PC films were bio-deteriorated and formed some “corrosion pits” on the PC film surface. In addition, strain NyZ600 performed broad depolymerization of PC indicated by the reduction of Mn from 23.55 to 16.75 kDa and Mw from 45.67 to 31.97 kDa and two degradation products bisphenol A and 4-cumylphenol (the two monomers of PC) were also found, which established that PC were biodegraded by strain NyZ600. Combing all above results, it is clear that the strain NyZ600 can degrade PC which provides a unique example for bacterial degradation of PC and a feasibility for the removal of PC waste.4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) were involved in the experimental procedure.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Name: 4-(2-Phenylpropan-2-yl)phenol 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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