Month: October 2022

Qiao, Juanjuan;Lu, Gengyu;Wu, Gang;Liu, Hui;Wang, Wanli;Zhang, Tianmao;Xie, Guoyong;Qin, Minjian published 《Influence of different pretreatments and drying methods on the chemical compositions and bioactivities of Smilacis Glabrae Rhizoma》. The research results were published in《Chinese Medicine (London, United Kingdom)》 in 2022.Formula: C23H32O2 The article conveys some information:

The processing of medicinal plant materials is one of the important factors influencing the components and biol. activities of TCMs. Smilax glabra Roxb. is an herbal vine widely distributed in China, and its dried rhizome (Smilacis Glabrae Rhizoma, SGR) is often used in traditional medicines and functional foods. The processing methods of fresh cutting for SGR slices have been included in ancient Chinese herbal works, some local standards of TCMs, and the current Chinese Pharmacopoeia. Nevertheless, to date, the scientific basis for the processing of fresh medicinal materials for SGR slices has not been revealed. To optimize the processing method for preparing SGR slices from the fresh rhizomes, the chem. compositions of the un-pretreated and pretreated (boiling, steaming) samples before and after drying (sun-drying, shade-drying, oven-drying), and the contents of astilbin isomers in dried SGR were analyzed by UHPLC-Q-TOF-MS/MS and UHPLC-DAD methods, resp. Then, the antioxidant, anti-inflammatory, xanthine oxidase and α-glucosidase inhibitory activities of the prepared SGR slices were investigated by biol. assays. A total of fifty-two compounds were identified from the un-pretreated and pretreated samples and a total of forty-nine compounds were identified from the subsequently dried samples. After pretreated by boiling and steaming, the contents of neoastilbin, neoisoastilbin, and isoastilbin in the prepared samples all increased. As a quality marker of SGR, the content of astilbin was unchanged or decreased slightly compared with that in the un-pretreated samples. During the drying process, the contents of the four astilbin stereoisomers in the un-pretreated samples increased significantly, while those in the pretreated samples had a slight increase or decrease. The effects of different processing methods were sorted according to the bioactivities of the prepared SGR. As a result, SGR slices prepared with no pretreatment followed by a sun-drying process have a higher astilbin content, better bioactivities and more energy savings, representing the optimum processing method for SGR slices. This study reveals the scientific basis for the processing of fresh medicinal materials for SGR slices. The results provide scientific information for the quality control of SGR and its rational applications in herbal medicines and functional foods. And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.

Formula: C23H32O22,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Min;Chen, Tieqiao;Zhou, Yongbo;Yin, Shuang-Feng published 《Transition metal-free oxidative ortho-acylation of phenols with N-heteroarylmethanes via double C-H activation》 in 2016. The article was appeared in 《Catalysis Science & Technology》. They have made some progress in their research.Product Details of 80-46-6 The article mentions the following:

The direct oxidative acylation of phenols with N-heteroarylmethanes via sp³C-H and sp²C-H double activation was achieved under transition metal-free reaction conditions. This transformation proceeded in a facile I₂/DMSO/O₂ system regioselectively to produce valuable (2-hydroxyphenyl)arylmethanones from easily available starting materials in moderate to good yields. A plausible mechanism was proposed. And 4-tert-Amylphenol (cas: 80-46-6) was used in the research process.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Product Details of 80-46-6

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application In Synthesis of 2-Hexyl-1-decanol《Toward the Prediction and Control of Glass Transition Temperature for Donor-Acceptor Polymers》 was published in 2020. The authors were Zhang, Song;Alesadi, Amirhadi;Selivanova, Mariia;Cao, Zhiqiang;Qian, Zhiyuan;Luo, Shaochuan;Galuska, Luke;Teh, Catherine;Ocheje, Michael U.;Mason, Gage T.;St. Onge, P. Blake J.;Zhou, Dongshan;Rondeau-Gagne, Simon;Xia, Wenjie;Gu, Xiaodan, and the article was included in《Advanced Functional Materials》. The author mentioned the following in the article:

Semiconducting donor-acceptor (D-A) polymers have attracted considerable attention toward the application of organic electronic and optoelectronic devices. However, a rational design rule for making semiconducting polymers with desired thermal and mech. properties is currently lacking, which greatly limits the development of new polymers for advanced applications. Here, polydiketopyrrolopyrrole (PDPP)-based D-A polymers with varied alkyl side-chain lengths and backbone moieties are systematically designed, followed by investigating their thermal and thin film mech. responses. The exptl. results show a reduction in both elastic modulus and glass transition temperature (T_g) with increasing side-chain length, which is further verified through coarse-grained mol. dynamics simulations. Informed from exptl. results, a mass-per-flexible bond model is developed to capture such observation through a linear correlation between T_g and polymer chain flexibility. Using this model, a wide range of backbone T_g over 80°C and elastic modulus over 400 MPa can be predicted for PDPP-based polymers. This study highlights the important role of side-chain structure in influencing the thermomech. performance of conjugated polymers, and provides an effective strategy to design and predict T_g and elastic modulus of future new D-A polymers. The experimental procedure involved many compounds, such as 2-Hexyl-1-decanol (cas: 2425-77-6) .

2-Hexyl-1-decanol(cas: 2425-77-6) has been shown to inhibit the growth of b16 mouse melanoma cells, suggesting it may be useful for treating skin cancer.Application In Synthesis of 2-Hexyl-1-decanol This fatty acid also has transport properties and can form hydrogen bonds with other molecules.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: 4-tert-OctylphenolIn 2021, Tang, Shuqin;Chen, Yukun;Song, Guixian;Liu, Xiaotu;Shi, Yumeng;Xie, Qitong;Chen, Da published 《A Cocktail of Industrial Chemicals in Lipstick and Nail Polish: Profiles and Health Implications》. 《Environmental Science & Technology Letters》published the findings. The article contains the following contents:

Beauty products contain various industrial chems. to increase their functionality and appearance. The frequent use of beauty products may increase human exposure to industrial chems., but to date, their chem. components remain poorly characterized. Our work characterized the chem. components in lipstick and nail polish by screening for a total of 231 chems. from seven categories, including organophosphate esters (OPEs), phthalate esters (PAEs), non-PAE plasticizers, bisphenol analogs, parabens, UV stabilizers, and antioxidants. Their total concentrations ranged from 38.9 to 3810 μg/g (median of 193 μg/g) and from 18.6 to 1910 μg/g (307 μg/g) in lipstick (n = 34) and nail polish (n = 15), resp. The chem. compositions differed between lipstick and nail polish, but non-PAE plasticizers generally dominated over other groups of chems. A number of emerging plasticizers, OPEs, and UV stabilizers have rarely been reported in personal care products or environmental samples but were found at very high levels in beauty products, raising concern about their environmental release and human exposure risk. Although the employment of a hazard quotient approach suggested low health risks for exposure to industrial chems. from the use of beauty products, potential mixture effects from the chem. cocktail and occupational exposure to beauty products should not be overlooked. The experimental procedure involved many compounds, such as 4-tert-Octylphenol (cas: 140-66-9) .

4-tert-Octylphenol(cas: 140-66-9) is a common environmental pollutant showing weak estrogenic effects.Recommanded Product: 4-tert-Octylphenol It has been shown to cause harm to vertebrate male reproductive systems.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Today I want to share an article with you. The article is 《Acridine-Based SNS-Ruthenium Pincer Complex-Catalyzed Borrowing Hydrogen-Mediated C-C Alkylation Reaction: Application to the Guerbet Reaction》,you can find this article in 《Synlett》. The following contents are mentioned:

SNS-based ruthenium pincer catalysts were applied in a Guerbet condensation reaction of primary alcs. to give β-alkylated dimeric alcs. I [R = Et, n-Bu, n-hexyl, etc.; R¹ = Me, n-Bu, n-hexyl, etc.] in good yields. The ability of these complexes to convert ethanol into butanol was also investigated. The work was then extended toward the C-alkylation of secondary alcs. with primary alcs. to give α-alkylated ketones II [R² = H, 4-OMe, 4-Me, etc. R³ = Ph, 4-ClC₆H₄, 4-FC₆H₄, etc.]. Several control experiments showed the involvement of borrowing hydrogen in the protocol. To complete the study, the researchers used 2-Hexyl-1-decanol (cas: 2425-77-6) .

2-Hexyl-1-decanol(cas: 2425-77-6) is a fatty acid that is found in the essential oils of plants and has been shown to have fungicidal properties.Electric Literature of C16H34O It has also been shown to inhibit the growth of Candida glabrata when used as a cationic surfactant.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

COA of Formula: C8H12ClNO2《Synthesis and biological activity of quaternary phosphonium salts based on 3-hydroxypyridine and 4-deoxypyridoxine》 was published in 2016. The authors were Shtyrlin, N. V.;Vafina, R. M.;Pugachev, M. V.;Khaziev, R. M.;Nikitina, E. V.;Zeldi, M. I.;Iksanova, A. G.;Shtyrlin, Yu. G., and the article was included in《Russian Chemical Bulletin》. The author mentioned the following in the article:

Methods for the synthesis of quaternary phosphonium salts based on 3-hydroxypyridine, e.g., I (HCl salt), and 4-deoxypyridoxine were developed. Some of obtained compounds possess high antibacterial and antitumor activity in vitro. The experimental procedure involved many compounds, such as 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 COA of Formula: C8H12ClNO2) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Name: 3,7-Dimethyloctan-3-ol《Biogenic volatile organic compound (BVOC) emissions from forested areas in Turkey: Determination of specific emission rates for thirty-one tree species》 was published in 2014. The authors were Aydin, Yagmur Meltem;Yaman, Baris;Koca, Husnu;Dasdemir, Okan;Kara, Melik;Altiok, Hasan;Dumanoglu, Yetkin;Bayram, Abdurrahman;Tolunay, Doganay;Odabasi, Mustafa;Elbir, Tolga, and the article was included in《Science of the Total Environment》. The author mentioned the following in the article:

Normalized biogenic volatile organic compound (BVOC) emission rates for 31 tree species which cover 98% of national forested areas in Turkey were determined Field sampling was performed at 14 forested areas using a specific dynamic enclosure system. Selected branches of tree species were enclosed in a chamber consisting of a transparent Nalofan bag. Air flow was sampled from chamber inlet and outlet by Tenax-filled sorbent tubes during tree photosynthesis in the presence of sunlight. Several environmental parameters (temperature, humidity, photosynthetically-active radiation [PAR], CO₂) were continuously monitored inside and outside the enclosure chamber during sampling. Collected samples were analyzed by gas chromatog./mass spectrometry with thermal desorption. In total, 65 BVOC classified in 5 major groups (isoprene, monoterpenes, sesquiterpenes, oxygenated sesquiterpenes, other oxygenated compounds) were analyzed. Emission rates were determined by normalization to standard conditions (1000 μmol/m²-s PAR and 30° for isoprene, 30°C for the remaining compounds). In agreement with the literature, isoprene was mostly emitted by broad-leaved trees while coniferous species mainly emitted monoterpenes. Several tree species (sweet chestnut, silver lime, European alder) had higher monoterpene emissions, although they are broad-leaved species. High isoprene emissions were also observed for several coniferous species (Nordmann fir, Oriental spruce). The highest normalized total BVOC emission rate, 27.1 μg/g-hm was observed for Oriental plane while southern European flowering ash was the weakest BVOC emitter with a total normalized emission rate of 0.031 μg/g-h. Monoterpene emissions from broad-leaved species mainly consisted of sabinene, limonene, and trans-β-ocimene; α- and β-pinene and β-myrcene were generally emitted by coniferous species. Oxygenated compounds were the third most prominent BVOC group; sesquiterpenes had slightly lower contributions. And 3,7-Dimethyloctan-3-ol (cas: 78-69-3) was used in the research process.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Name: 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 4-(2-Phenylpropan-2-yl)phenolIn 2019, Tanaka, Kumpei;Gotoh, Hiroaki published 《Development of the radical C-O coupling reaction of phenols toward the synthesis of natural products comprising a diaryl ether skeleton》. 《Tetrahedron》published the findings. The article contains the following contents:

Compounds comprising a diaryl ether skeleton exist among natural phenols. The diaryl ether skeleton is thought to be biosynthesized through the coupling of two or more phenols. It is an important structural feature in medicines and agrochems., and it is imperative to develop methods for constructing such skeletons in organic synthesis. However, by the synthesis method through the coupling of phenols, coupling occurs preferentially at the ortho-substituted carbon atom of phenols. In this study, various radical-generating reagents and conditions were investigated with the aim of developing a short-step construction method of the diaryl ether skeleton by the radical homo-coupling of two phenol mols. In addition, cross-coupling reactions between radicals of 2,4,6-tri-tert-butylphenol and p-substituted phenol were conducted to synthesize eight C (ortho)-O coupling products. Based on the results, a computational chem. approach was employed to verify the cause of C (ortho)-O bond formation. And 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) was used in the research process.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Reference of 4-(2-Phenylpropan-2-yl)phenol 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Category: alcohols-buliding-blocks《Cooperative interaction between acid and copper resistance in Escherichia coli》 was published in 2022. The authors were Kim, Yeeun;Lee, Seohyeon;Park, Kyungah;Yoon, Hyunjin, and the article was included in《Journal of Microbiology and Biotechnology》. The author mentioned the following in the article:

The persistence of pathogenic Escherichia coli under acidic conditions poses a serious risk to food safety, especially in acidic foods such as kimchi. To identify the bacterial factors required for acid resistance, transcriptomic anal. was conducted on an acid-resistant enterotoxigenic E. coli strain and the genes with significant changes in their expression under acidic pH were selected as putative resistance factors against acid stress. These genes included those associated with a glutamatedependent acid resistance (GDAR) system and copper resistance. E. coli strains lacking GadA, GadB, or YbaST, the components of the GDAR system, exhibited significantly attenuated growth and survival under acidic stress conditions. Accordantly, the inhibition of the GDAR system by 3- mercaptopropionic acid and aminooxyacetic acid abolished bacterial adaptation and survival under acidic conditions, indicating the indispensable role of a GDAR system in acid resistance. Intriguingly, the lack of cueR encoding a transcriptional regulator for copper resistance genes markedly impaired bacterial resistance to acid stress as well as copper. Conversely, the absence of YbaST severely compromised bacterial resistance against copper, suggesting an interplay between acid and copper resistance. These results suggest that a GDAR system can be a promising target for developing control measures to prevent E. coli resistance to acid and copper treatments. And 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) was used in the research process.

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Category: alcohols-buliding-blocks) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

COA of Formula: C23H32O2In 2021, Tang, Shuqin;Chen, Yukun;Song, Guixian;Liu, Xiaotu;Shi, Yumeng;Xie, Qitong;Chen, Da published 《A Cocktail of Industrial Chemicals in Lipstick and Nail Polish: Profiles and Health Implications》. 《Environmental Science & Technology Letters》published the findings. The article contains the following contents:

Beauty products contain various industrial chems. to increase their functionality and appearance. The frequent use of beauty products may increase human exposure to industrial chems., but to date, their chem. components remain poorly characterized. Our work characterized the chem. components in lipstick and nail polish by screening for a total of 231 chems. from seven categories, including organophosphate esters (OPEs), phthalate esters (PAEs), non-PAE plasticizers, bisphenol analogs, parabens, UV stabilizers, and antioxidants. Their total concentrations ranged from 38.9 to 3810 μg/g (median of 193 μg/g) and from 18.6 to 1910 μg/g (307 μg/g) in lipstick (n = 34) and nail polish (n = 15), resp. The chem. compositions differed between lipstick and nail polish, but non-PAE plasticizers generally dominated over other groups of chems. A number of emerging plasticizers, OPEs, and UV stabilizers have rarely been reported in personal care products or environmental samples but were found at very high levels in beauty products, raising concern about their environmental release and human exposure risk. Although the employment of a hazard quotient approach suggested low health risks for exposure to industrial chems. from the use of beauty products, potential mixture effects from the chem. cocktail and occupational exposure to beauty products should not be overlooked. To complete the study, the researchers used 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

COA of Formula: C23H32O22,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts