Month: October 2022

Yan, Yuzhu;Wang, Jihan;Huang, Dageng;Lv, Jing;Li, Hui;An, Jing;Cui, Xiaojian;Zhao, Heping published 《Plasma lipidomics analysis reveals altered lipids signature in patients with osteonecrosis of the femoral head》. The research results were published in《Metabolomics》 in 2022.Category: alcohols-buliding-blocks The article conveys some information:

Although studies have established a link between lipid metabolism disorder and osteonecrosis of the femoral head (ONFH), the characteristics of the circulating lipidome signature of ONFH have not yet been investigated and need to be explored. We aimed to explore the plasma lipidome signatures in patients with ONFH, and to identify specific lipid biomarkers of ONFH. In this study, a comprehensive detection and anal. of plasma lipidomics was conducted in clin. human cohort, including 32 healthy normal control (NC) subjects and 91 ONFH patients in different subgroups [alc.-induced ONFH (AONFH), steroid-induced ONFH (SONFH), and traumatic-induced ONFH (TONFH)] or at different disease stages (stage I, II, III and IV of ONFH) using ultra-high performance liquid chromatog.-tandem mass spectrometry (UHPLC-MS/MS). Overall, the plasma lipidome profile differs between ONFH and NC samples. Lipidome signature including 22 common differentially expressed lipids (DELs) in all three subgroups (variable importance in projection > 1, P < 0.05, fold change > 1.5 or < 0.67, compared to the NC group) was identified. Besides, the subtype-specific lipidome profiles for each ONFH subgroup were also analyzed. Generally, the AONFH subgroup has the largest number of DELs, and the plasma levels of triacylglycerol lipid compounds increased obviously in the AONFH samples. In the subgroup of SONFH, the relative abundance of lipid 4-Aminobenzoic acid increased significantly with changes in the expression of several of its interactive genes. We have identified that 9 stage-pos. and 2 stage-neg. lipids may function as novel biomarkers predicting the progression of ONFH. Our study presents an overview of the phenotype-related plasma lipidome signature of patients with ONFH. The results will provide insight into the mechanisms underlying the metabolism of lipids in the pathogenesis and progression of ONFH and help identify novel lipids biomarkers or disease diagnosis and treatment targets.4-tert-Amylphenol (cas: 80-46-6) were involved in the experimental procedure.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Category: alcohols-buliding-blocks

Reference:
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Recommanded Product: 2,2-Methylenebis(6-tert-butyl-p-cresol)In 2022, Dai, Chenbo;Yang, Libin;Wang, Jun;Li, Dezhen;Zhang, Yalei;Zhou, Xuefei published 《Enhancing anaerobic digestion of pharmaceutical industries wastewater with the composite addition of zero valent iron (ZVI) and granular activated carbon (GAC)》. 《Bioresource Technology》published the findings. The article contains the following contents:

Anaerobic digestion of pharmaceutical wastewater is challenged by its contained toxic compounds which limits the stability and efficiency of methane production and organic degradation In this study, zero valent iron (ZVI) and granular activated carbon (GAC) were added with different strategies to improve anaerobic digestion of pharmaceutical wastewater. The results confirmed synergy effects of ZVI + GAC for both COD removal (increased by 13.4%) and methane production (increased by 11.0%). Furthermore, ZVI + GAC improved the removal of pharmaceutical intermediates, in particular, the residues (%) of dehydroepiandrosterone (DHEA) and 2,2′-methylenebis(6-tert-butyl-4-methylphenol) were only 30.48 ± 6.53 and 39.92 ± 4.50, and effectively reduced biotoxicity. The promoted results were attributed to the establishment of direct interspecies electron transfer (DIET). Microbial community anal. revealed that ZVI + GAC decreased species evenness and richness in bacterial whereas increased in archaeal. The relative abundance of acetotrophic methanogens decreased but hydrogenotrophic and methylotrophic methanogens increased, which broadening the pathway of methane production The experimental procedure involved many compounds, such as 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Recommanded Product: 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

Reference:
Alcohol – Wikipedia,
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Pilevar, Afsaneh;Hosseini, Abolfazl;Becker, Jonathan;Schreiner, Peter R. published 《Syn-Dihydroxylation of Alkenes Using a Sterically Demanding Cyclic Diacyl Peroxide》 in 2019. The article was appeared in 《Journal of Organic Chemistry》. They have made some progress in their research.Name: rel-(1R,2S)-1,2-Diphenylethane-1,2-diol The article mentions the following:

The syn-dihydroxylation of alkenes is a highly valuable reaction in organic synthesis. Cyclic acyl peroxides (CAPs) have emerged recently as promising candidates to replace the commonly employed toxic metals for this purpose. Here, we demonstrate that the structurally demanding cyclic peroxide spiro[bicyclo[2.2.1]heptane-2,4′-[1,2]dioxolane]-3′,5′-dione (P4) can be effectively used for the syn-dihydroxylation of alkenes. Reagent P4 also shows an improved selectivity for dihydroxylation of alkenes bearing β-hydrogens as compared to other CAPs, where both diol and allyl alc. products compete with each other. Furthermore, the use of enantiopure P4 (labeled P4′) demonstrates the potential of P4′ for a metal-free asym. syn-dihydroxylation of alkenes. And rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) was used in the research process.

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Name: rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Siu, Timothy C.;Silva, Israel Jr;Lunn, Maiko J.;John, Alex published 《Influence of the pendant arm in deoxydehydration catalyzed by dioxomolybdenum complexes supported by amine bisphenolate ligands》 in 2020. The article was appeared in 《New Journal of Chemistry》. They have made some progress in their research.SDS of cas: 579-43-1 The article mentions the following:

Dioxomolybdenum complexes supported by aminebisphenolate ligands were evaluated for their potential in catalyzing the deoxydehydration (DODH) reaction to establish structure-activity relationships. The nature of the pendant arm in these aminebisphenolate ligands was found to be crucial in determining reactivity in the deoxydehydration of styrene glycol (1-phenyl-1,2-ethanediol) to styrene. Pendant arms bearing strongly coordinating N-based groups such as pyridyl or amino substituents were found to hinder activity while those bearing non-coordinating pendant arms (benzyl) or even weakly coordinating groups (an ether) resulted in up to 6 fold enhanced catalytic activity. A dioxomolybdenum complex featuring an aminemonophenolate ligand derived from the aminebisphenolate skeleton also resulted in similar yield enhancements. Although aromatic solvents were found to be ideal for performing these catalytic reactions, polar solvents such as N,N-dimethylformamide (DMF) and N,N’-dimethylpropyleneurea (DMPU) were also suitable. The catalyst was found to maintain its structural integrity under the optimized conditions and could be recycled for a second catalytic run without loss of activity. With the activated substrate meso-hydrobenzoin, trans-stilbene was obtained in a 56% yield at 220°C along with benzaldehyde (71%) suggesting that the diol was a competing reductant under these conditions.rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) were involved in the experimental procedure.

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 SDS of cas: 579-43-1) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

Reference:
Alcohol – Wikipedia,
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HPLC of Formula: 80-46-6In 2016, Kluever, Nils;Vogs, Carolina;Altenburger, Rolf;Escher, Beate I.;Scholz, Stefan published 《Development of a general baseline toxicity QSAR model for the fish embryo acute toxicity test》. 《Chemosphere》published the findings. The article contains the following contents:

Fish embryos have become a popular model in ecotoxicol. and toxicol. The fish embryo acute toxicity test (FET) with the zebrafish embryo was recently adopted by the OECD as tech. guideline TG 236 and a large database of concentrations causing 50% lethality (LC₅₀) is available in the literature. Quant. Structure-Activity Relationships (QSARs) of baseline toxicity (also called narcosis) are helpful to estimate the min. toxicity of chems. to be tested and to identify excess toxicity in existing data sets. Here, we analyzed an existing fish embryo toxicity database and established a QSAR for fish embryo LC₅₀ using chems. that were independently classified to act according to the non-specific mode of action of baseline toxicity. The octanol-water partition coefficient K_ow is commonly applied to discriminate between non-polar and polar narcotics. Replacing the K_ow by the liposome-water partition coefficient K_lipw yielded a common QSAR for polar and non-polar baseline toxicants. This developed baseline toxicity QSAR was applied to compare the final mode of action (MOA) assignment of 132 chems. Further, we included the anal. of internal lethal concentration (ILC₅₀) and chem. activity (La₅₀) as complementary approaches to evaluate the robustness of the FET baseline toxicity. The anal. of the FET dataset revealed that specifically acting and reactive chems. converged towards the baseline toxicity QSAR with increasing hydrophobicity. The developed FET baseline toxicity QSAR can be used to identify specifically acting or reactive compounds by determination of the toxic ratio and in combination with appropriate endpoints to infer the MOA for chems. The experimental procedure involved many compounds, such as 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. HPLC of Formula: 80-46-6

Reference:
Alcohol – Wikipedia,
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Lewandowski, Andrzej;Szymczyk, Katarzyna published 《Adsorption of monoterpene alcohols at the water-air interface》 in 2019. The article was appeared in 《Adsorption》. They have made some progress in their research.HPLC of Formula: 78-69-3 The article mentions the following:

The measurements of the surface tension of aqueous solutions of 10 monoterpene alcs., MAs: (-)-β-citronellol, geraniol, tetrahydrolinalool, linalool, (-)-menthol, (-)-terpinen-4-ol, p-cymene-8-ol, α-terpineol, isoborneol and (-)-borneol were made at T = 293 K. On the basis of the obtained results the values of the adsorption constant, the excluded area per mol. at the interface and the interaction parameter were determined by fitting the exptl. data to various adsorption models. Next the adsorption free energy of studied MAs was determined and discussed in terms of the preferred orientation of studied MAs at the water-air interface and mol. structure of MAs. The experimental procedure involved many compounds, such as 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.HPLC of Formula: 78-69-3 Metabolite observed in cancer metabolism. It has a role as a human metabolite.

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Alcohol – Wikipedia,
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Electric Literature of C11H16OIn 2019, Zhang, Zhen;Ruan, Zhiyong;Liu, Jin;Liu, Chang;Zhang, Fuming;Linhardt, Robert J.;Li, Lin published 《Complete degradation of bisphenol A and nonylphenol by a composite of biogenic manganese oxides and Escherichia coli cells with surface-displayed multicopper oxidase CotA》. 《Chemical Engineering Journal (Amsterdam, Netherlands)》published the findings. The article contains the following contents:

Endocrine-disrupting chems. (EDCs) are a large group of environmental toxicants that pose serious risks to public health. In this study, we report a new method for the complete degradation of EDCs using a dual oxidation-action composite of biogenic manganese oxides and engineered Escherichia coli cells with surface-expressed multicopper oxidase CotA. The cotA gene from a Mn²⁺-oxidizing bacterium was constructed as a fusion gene “inaQ-N/cotA” with an anchoring motif inaQ-N from Pseudomonas syringae and was expressed in E. coli cells to display catalytic CotA on the cell surface. Under prolonged Mn²⁺-enriched culturing conditions, the engineered cells were capable of forming microspherical aggregated composites that were mainly composed of ramsdellite (MnO₂). The ability of the composite to degrade two EDCs, bisphenol A (BPA) and nonylphenol (NP), was investigated. GC-MS assays identified 7 and 10 degraded intermediates using the ¹³C isotope from ¹³C-labeled BPA and ¹³C-labeled NP, resp. The appearance of ¹³CO₂ from both reaction mixtures revealed mineralization pathways of BPA and NP by this composite. Bioassays using Caenorhabditis elegans as an indicator organism demonstrated that the estrogenic activity of BPA and NP was eliminated by these degradation processes. The reaction of the composite proceeded at an acidic pH and room temperature A consecutive three-round treatment process showed comparable levels of degradation by the composite in repeated reactions and showed that the activity could be easily recovered. Moreover, the superoxide radical levels of BPA-degradation and NP-degradation were monitored during the 24 h reaction time, and possible BPA-degradation and NP-degradation pathways by the composite were proposed. The experimental procedure involved many compounds, such as 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Electric Literature of C11H16O

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Kobayashi, Daiki;Kodama, Shintaro;Ishii, Youichi published 《An oxidovanadium(IV) complex having a perrhenato ligand: An efficient catalyst for aerobic oxidation reactions of benzylic and propargylic alcohols》 in 2017. The article was appeared in 《Tetrahedron Letters》. They have made some progress in their research.Quality Control of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol The article mentions the following:

An oxidovanadium(IV) complex having a perrhenato ligand [VO(ReO₄)(4,4′-^tBubpy)₂][0.25SO₄·0.5ReO₄] (4,4′-^tBubpy = 4,4′-di-tert-butyl-2,2′-bipyridine) efficiently catalyzes not only dehydrogenative oxidation of benzylic and propargylic mono-alcs. but also oxidative C-C bond cleavage of meso-1,2-diaryl-1,2-ethanediols under atm. mol. oxygen, affording the corresponding carbonyl compounds in good yield. And rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) was used in the research process.

rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas: 579-43-1 Quality Control of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) has been used in the preparation of trans-methyl meso-hydrobenzoin phosphite.

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Liebold, Martin;Sharikow, Eugen;Seikel, Elisabeth;Trombach, Lukas;Harms, Klaus;Zimcik, Petr;Novakova, Veronika;Tonner, Ralf;Sundermeyer, Joerg published 《An experimental and computational study on isomerically pure, soluble azaphthalocyanines and their complexes and boron azasubphthalocyanines of a varying number of aza units》 in 2018. The article was appeared in 《Organic & Biomolecular Chemistry》. They have made some progress in their research.Related Products of 110-03-2 The article mentions the following:

Herein, the authors present a series of isomerically pure, peripherally alkyl substituted, soluble and low aggregating azaphthalocyanines as well as their new, smaller hybrid homologs, azasubphthalocyanines. The focus lies on the effect of the systematically increasing number of aza building blocks [-N=] replacing the non-peripheral [-CH=] units and their influence on the phys. and photophys. properties of these chromophores. The absolute and relative HOMO-LUMO energies of azaphthalocyanines were analyzed using UV-visible and CV and compared to the d. functional theory calculations (B3LYP, TD-DFT). The lowering of the HOMO level is revealed as the determining factor for the trend in the adsorption energies by electronic structure anal. Crystals of substituted subphthalocyanines, N₂-Pc*H₂ and N₄-[Pc*Zn·H₂O], were obtained out of DCM. For the synthesis of the valuable tetramethyltetralin phthalocyanine building block a new highly efficient synthesis involving a nearly quant. Co^II catalyzed aerobic autoxidation step is introduced replacing inefficient KMnO₄/pyridine as the oxidant. And 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) was used in the research process.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) is used as an intermediate in the preparation of 2.5-Dimethyl-2.5-bis(tertbutyl-peroxy)hexane. It is also used in the synthesis of six- and seven-membered heterocyclic boron compounds.Related Products of 110-03-2

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Category: alcohols-buliding-blocks《A star-shaped solid composite electrolyte containing multifunctional moieties with enhanced electrochemical properties for all solid-state lithium batteries》 was published in 2018. The authors were Zhang, Jinfang;Ma, Cheng;Hou, Hua;Li, Xiaofeng;Chen, Libao;Ivey, Douglas G.;Wei, Weifeng, and the article was included in《Journal of Membrane Science》. The author mentioned the following in the article:

Limited ionic conduction and poor solid/solid interfacial stability are crucial characteristics that impede the practical application of solid polymeric electrolytes. Herein, a star-shaped solid composite electrolyte (SCE) containing multifunctional components, including anion-trapping boron moieties (B-PEGMA), poly(ethylene glycol)methyl ether methacrylate (PEGMEM) and octavinyl octasilsesquioxane (OV-POSS) nanofiller, was developed via a simple free radical polymerization method. The unique star-shaped structure induced by OV-POSS is beneficial to increasing the movement of polymer chains and forming continuously interconnected ion-conducting channels and the boron moieties can promote lithium salt dissociation and increase the effective transmission of Li⁺ in the electrolyte. This SCE exhibits an extremely high ionic conductivity of 3.44 × 10^-4 S cm^-1 and a high Li ion transference number of 0.58 at 25°C, as well as excellent interfacial compatibility with the Li electrode leading to excellent rate performance and good cyclic stability in all-solid-state Li batteries. To complete the study, the researchers used 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) is used as an intermediate in the preparation of 2.5-Dimethyl-2.5-bis(tertbutyl-peroxy)hexane. It is also used in the synthesis of six- and seven-membered heterocyclic boron compounds.Category: alcohols-buliding-blocks

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