Month: October 2022

Formula: C15H16O《Accelerated SuFEx Click Chemistry For Modular Synthesis》 was published in 2022. The authors were Smedley, Christopher J.;Homer, Joshua A.;Gialelis, Timothy L.;Barrow, Andrew S.;Koelln, Rebecca A.;Moses, John E., and the article was included in《Angewandte Chemie, International Edition》. The author mentioned the following in the article:

The development of accelerated SuFEx click chem. (ASCC), an improved SuFEx method for the efficient and catalytic coupling of aryl and alkyl alcs. with a range of SuFExable hubs was reported. Barton’s hindered guanidine base (2-tert-butyl-1,1,3,3-tetramethylguanidine; BTMG) was demonstrated as a superb SuFEx catalyst, when used in synergy with silicon additive hexamethyldisilazane (HMDS), yielded stable S-O bond linkages in a single step; often within minutes. The powerful combination of BTMG and HMDS reagents allowed for catalyst loadings as low as 1.0 mol % and in congruence with click-principles, provided a scalable method that is safe, efficient and practical for modular synthesis. ASSC expands the number of accessible SuFEx products and will find significant application in organic synthesis, medicinal chem., chem. biol., and materials science. And 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) was used in the research process.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Formula: C15H16O 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Pan, Liangkun;Ke, Zhihai;Yeung, Ying-Yeung published 《Lewis Base Catalyzed Dioxygenation of Olefins with Hypervalent Iodine Reagents》. The research results were published in《Organic Letters》 in 2021.Category: alcohols-buliding-blocks The article conveys some information:

1,2-Diols were extremely useful building blocks in organic synthesis. Hypervalent iodine reagents were useful for the vicinal dihydroxylation of olefins to gave 1,2-diols under metal-free conditions, but strongly acidic promoters were often required. Herein, synthesis of 1,2-diols R¹CHOHCHOHR² [R¹ = n-hexyl, Ph, Bn, etc.; R² = H, Ph] and acetals R³CH₂CH(OMe)₂ [R³ = Ph, 4-MeOC₆H₄, (4-acetoxyphenyl), etc.] via catalytic vicinal dioxygenation of olefins with hypervalent iodine reagents using Lewis bases as catalysts was reported. The conditions were mild and compatible with various functional groups. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Category: alcohols-buliding-blocks) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Hu, Junjie;Liu, Jinhuan;Lv, Xiaomei;Yu, Lili;Lan, Shanhong;Li, Yanliang;Yang, Yan published 《Assessment of epigenotoxic profiles of Dongjiang River: A comprehensive of chemical analysis, in vitro bioassay and in silico approach》 in 2021. The article was appeared in 《Environmental Pollution (Oxford, United Kingdom)》. They have made some progress in their research.Product Details of 140-66-9 The article mentions the following:

This research explored the occurrence, epigenetic toxic profiling and main toxic pollutants of POPs in surface water of Dongjiang River, southern China. The concentrations of selected POPs including polycyclic aromatic hydrocarbons (PAHs), endocrine disrupting chems. (EDCs), phthalate esters (PAEs) and polybrominated di-Ph ethers (PBDEs) of surface water from 18 sites were investigated. ∑16PAHs and ∑4EDCs were at a moderate level, while ∑6PAEs and ∑6PBDEs had low pollution levels. PAHs, EDCs and PAEs showed higher concentrations in dry season than those in wet season, and the loading of selected POPs in tributaries was higher than those in mainstream due to intensive manufactures and lower runoff volume Moreover, activities of DNA methyltransferase (DNMT)1, histone deacetylase (HDAC2, HDAC8) were confirmed to be sensitive indicators for epigenetic toxicity. The DNMT1-mediated epigenetic equivalency toxicity of organic extracts in Dongjiang River were more serious than those of HDAC2 and HDAC8. Correlation anal. shown binding affinity between POPs and DNMT1, HDAC2 and HDAC8 could be regarded as toxic equivalency factors. Risk assessment suggested that 4-nonylphenol and bisphenol A were the largest contributors to epigenetic risk. This study is the first attempt to quantify epigenetic toxicity and epigenetic risk evaluation of river water.4-tert-Octylphenol (cas: 140-66-9) were involved in the experimental procedure.

4-tert-Octylphenol(cas: 140-66-9) has been used as a reference standard for the determination of the analyte in water samples using ultra-high-performance liquid chromatography/tandem mass spectrometry (UHPLC/MS/MS).Product Details of 140-66-9

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Safety of rel-(1R,2S)-1,2-Diphenylethane-1,2-diolIn 2020, Chatterjee, Gourav;Shadangi, Krushna Prasad;Mohanty, Kaustubha published 《Effect of Catalyst Bed Height on the Yield and Composition of Non-edible Seed Pyrolytic Oil》. 《Waste and Biomass Valorization》published the findings. The article contains the following contents:

The thermal and catalytic vapor cracking of non-edible seed such as Kassod seed was studied in a fixed bed reactor. The effect of temperature on the yield of pyrolytic liquid was observed from thermal pyrolysis and the optimum temperature was determined At the optimum temperature catalytic vapor cracking using CaO was studied by varying the catalyst loading as well as the bed height. The effect of catalyst loading and bed height on the yield, fuel properties, distillation temperature and composition of pyrolytic oil were determined The results confirmed that thermal pyrolysis of Kassod seed at 550°C yielded 50.21 wt% of pyrolytic liquid containing 39.86 wt% and 10.35 wt% organic and aqueous phase resp. The highest yield of pyrolytic oil (organic liquid) was 31.2 wt% and 22.95 wt% obtained at 2 wt% loading of catalyst at a bed height of 8.5 cm and 11.1 cm resp. The effect of catalytic vapor cracking with the variation in the bed height on the fuel properties confirmed that increasing the catalyst bed height raised the basicity of the pyrolytic oil. The gross calorific value of the oil increased at higher wt% of catalyst loading and were better at the catalyst bed height of 11.1 cm. The catalytic vapor cracking enhanced the fuel properties of the pyrolytic oil by the formation of more volatile components in the pyrolytic oil. The variation in the composition of the pyrolytic oil with and without catalyst was confirmed from the GC-MS anal.rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) were involved in the experimental procedure.

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Safety of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Reference of 2-Hexyl-1-decanol《Chemosensory approach supported-analysis of wintering radishes produced in Jeju island by different processing methods》 was published in 2021. The authors were Hong, Seong Jun;Boo, Chang Guk;Lee, Jookyeong;Hur, Seong Wook;Jo, Seong Min;Jeong, Hyangyeon;Yoon, Sojeong;Lee, Youngseung;Park, Sung-Soo;Shin, Eui-Cheol, and the article was included in《Food Science and Biotechnology》. The author mentioned the following in the article:

The purpose of this study was to investigate sensory characteristics in radishes, processed through different methods, using chemosensory-assisted instruments. For electronic tongue (E-tongue) anal., freeze-dried radish was high in the sensor values of sourness, umami, and sweetness, however, the saltiness was the lowest. In particular, the sensor values of taste freeze-dried radish have changed more than that of thermally processed radishes. Unlike the results of E-tongue, volatiles of freeze-dried radish have changed less than that of thermally processed radishes. In detail, amounts of sulfur-containing compound (thiophene) in freeze-dried radish were relatively higher than thermally processed radishes by an electronic nose. For gas chromatog.-mass spectrometry and GC-olfactometry, the amount of sulfur-containing compounds in freeze-dried radish were also relatively higher than thermally processed radishes, and odor active compounds were also high in freeze-dried radish.2-Hexyl-1-decanol (cas: 2425-77-6) were involved in the experimental procedure.

2-Hexyl-1-decanol(cas: 2425-77-6) is a fatty acid that is found in the essential oils of plants and has been shown to have fungicidal properties.Reference of 2-Hexyl-1-decanol It has also been shown to inhibit the growth of Candida glabrata when used as a cationic surfactant.

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Guan, Honghao;Sun, Shutao;Mao, Ying;Chen, Lei;Lu, Ran;Huang, Jiancheng;Liu, Lei published 《Iron(II)-Catalyzed Site-Selective Functionalization of Unactivated C(sp³)-H Bonds Guided by Alkoxyl Radicals》 in 2018. The article was appeared in 《Angewandte Chemie, International Edition》. They have made some progress in their research.Recommanded Product: 78-69-3 The article mentions the following:

An alkoxyl radical guided strategy for site-selective functionalization of unactivated methylene and methine C-H bonds enabled by an Fe^II-catalyzed redox process is described. The mild, expeditious, and modular protocol allows efficient remote aliphatic fluorination, chlorination, amination, and alkynylation of structurally and electronically varied primary, secondary, and tertiary hydroperoxides with excellent functional-group tolerance. The application for one-pot 1,4-hydroxyl functionalization of non-oxygenated alkane substrates initiated by aerobic C-H oxygenation is also demonstrated. The experimental procedure involved many compounds, such as 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Recommanded Product: 78-69-3 Metabolite observed in cancer metabolism. It has a role as a human metabolite.

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Huang, Shiyang;McDonald, James A.;Kuchel, Rhiannon P.;Khan, Stuart J.;Leslie, Greg;Tang, Chuyang Y.;Mansouri, Jaleh;Fane, Anthony G. published 《Surface modification of nanofiltration membranes to improve the removal of organic micropollutants: Linking membrane characteristics to solute transmission》 in 2021. The article was appeared in 《Water Research》. They have made some progress in their research.HPLC of Formula: 140-66-9 The article mentions the following:

Surface modification of nanofiltration (NF) membranes has great potential to improve the removal of organic micropollutants (OMs) by NF membranes. This study used polydopamine (PDA) as a model coating to comprehensively link the changes in membrane properties with the changes in transmission of 34 OMs. The membrane characterization demonstrated that a thicker, denser, and more hydrophilic PDA coating can be achieved by increasing the PDA deposition time from 0.5 to 4 h. Overall, the transmissions of target OMs were reduced by PDA-coated NF membranes compared to unmodified NF membranes. The neutral hydrophobic compounds showed lower transmissions for longer PDA coating (PDA4), while the neutral hydrophilic compounds tended to show lower transmissions for shorter PDA coating (PDA0.5). To explain this, competing effects provided by the PDA coatings are proposed including sealing defects, inducing cake-enhanced concentration polarization in the coating layer for neutral hydrophilic compounds, and weakened hydrophobic adsorption for neutral hydrophobic compounds For charged compounds, PDA4 with the greatest neg. charge among the PDA-coated membranes showed the lowest transmission. Depending on the mol. size and hydrophilicity of the compounds, the transmission of OMs by the PDA4 coating could be reduced by 70% with only a 26.4% decline in water permeance. The correlations and mechanistic insights provided by this work are highly useful for designing membranes with sp. surface properties via surface modification to improve the removal of OMs without compromising water production To complete the study, the researchers used 4-tert-Octylphenol (cas: 140-66-9) .

4-tert-Octylphenol(cas: 140-66-9) is a common environmental pollutant showing weak estrogenic effects.HPLC of Formula: 140-66-9 It has been shown to cause harm to vertebrate male reproductive systems.

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Aszyk, Justyna;Wozniak, Mateusz Kacper;Kubica, Pawel;Kot-Wasik, Agata;Namiesnik, Jacek;Wasik, Andrzej published 《Comprehensive determination of flavouring additives and nicotine in e-cigarette refill solutions. Part II: Gas-chromatography-mass spectrometry analysis》. The research results were published in《Journal of Chromatography A》 in 2017.HPLC of Formula: 78-69-3 The article conveys some information:

Flavouring compounds are an essential part of e-liquid products for cigarettes. In general, they are regarded as safe for ingestion, but they may have unrecognized risks when they are inhaled. In some cases, manufactures do not currently abide by the Tobacco Products Directive (2014/40/EU) and do not declare the detailed contents of e-liquids on their labels. To help evaluate the health impact of flavouring substances, there is a need for comprehensive approaches to determine their concentrations in e-liquids For this purpose, a GC-EI-MS method was developed and validated for the simultaneous determination of 46 commonly used flavor additives in e-liquids The proposed method performed well in terms of the key validation parameters: accuracy (84-113%), inter-/intra-day precision: 0.1-10% and 1-11%, resp., and sensitivity (limit of detection: 3-87 ng/mL). The sample preparation step was based on a simple “dilute & shoot” approach. This study is a complementary method to the LC-MS/MS procedure described in Part I. Both approaches are suitable for the comprehensive determination of 88 flavouring compounds and nicotine and can be used as tools for the rapid evaluation of the quality and safety of e-cigarette products.3,7-Dimethyloctan-3-ol (cas: 78-69-3) were involved in the experimental procedure.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.HPLC of Formula: 78-69-3 Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
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Synthetic Route of C16H34OIn 2022, Chen, Qing;Jiang, Xin;Xiao, Naiyong;Feng, Qian;Liu, Junya;Shi, Wenzheng published 《Characterization of the effect of different sugar on volatile flavor compounds of dried fish floss using e-nose combined with HS-SPME / GC-MS》. 《Journal of Food Processing and Preservation》published the findings. The article contains the following contents:

The aim of this study was to evaluate volatile compounds of dried fish floss with different sugar using electronic nose (e-nose) and headspace-solid-phase microextraction/gas chromatog.-mass spectrometry (HS-SPME/GC-MS). Maillard reaction (MR) was carried out by reducing sugar (glucose, xylose, fructose, and galactose) instead of sucrose to increase the flavor of fish floss. The results showed that 64 volatile compounds were detected in fish floss. Hexanal, heptanal, nonanal, decanal, undecanal, tridecanal, pentadecanal, 4-ethyl-benzaldehyde, dodecanal, benzene acetaltaldehyde, (E, E)-2,6-nonadienal, (E, E)-2,4-decadienal, 2-undecanone, 1-octen-3-ol, (E)-2-hepten-1-ol, 1-heptanol, and 2-pentyl-furan were regarded as key volatile compounds Furthermore, e-nose and partial least squares-discriminant anal. (PLS-DA) showed that there were significant differences in flavor among fish floss samples. The correlation anal. of browning index, fatty acids, and key volatile compounds confirmed that MR and lipid oxidation made a great contribution to the flavor formation. These results might provide guidance for the production and flavor formation of fish floss. Practical applications : Dried fish floss deeply loved by the public is a traditional leisure food with unique odor and delicious taste. The attractive flavor of dried fish floss could be increased with the help of the Maillard reaction (MR). The type of sugar in MR has a great influence on the reaction process and the flavor of substances. The comprehensive information on the flavor among the dried fish floss with different sugar (sucrose, glucose, xylose, fructose, and galactose) was characterized by using HS-SPME/GC-MS, electronic nose (E-nose), and fatty acid anal., which may provide a reference for the quality improvement of dried fish floss. To complete the study, the researchers used 2-Hexyl-1-decanol (cas: 2425-77-6) .

2-Hexyl-1-decanol(cas: 2425-77-6) may be employed as an organic solvent to study the extraction of non-polar acidic drugs from human plasma by parallel artificial liquid membrane extraction (PALME). Synthetic Route of C16H34O

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North, Megan K.;Dalle Zotte, Antonella;Hoffman, Louwrens C. published 《The effects of dietary quercetin supplementation on the meat quality and volatile profile of rabbit meat during chilled storage》 in 2019. The article was appeared in 《Meat Science》. They have made some progress in their research.Application of 80-46-6 The article mentions the following:

Thirty-four New Zealand White rabbits of both sexes were fed a control or supplemented (2 g/kg quercetin dihydrate) diet from weaning until slaughter (13 wk). After post-mortem chilling, excised and minced Longissimus thoracis et lumborum muscles were stored at 3.2 °C under oxygen-permeable wrapping for 1, 3 or 5 days. Color, pH, lipid oxidation (TBARS), antioxidant capacity (FRAP), volatile profile (day 1 and 5) and microbial count (day 5) were determined Quercetin reduced alkane (day 5) and hexanal (day 1) concentrations, but otherwise had minimal antioxidant effect, and did not benefit microbial quality, and thus did not substantially improve the shelf-life. The sex effect was similarly limited. Overall, the pH increased and FRAP decreased during storage, but TBARS did not change and discoloration seemed delayed. The volatile profile was dominated by esters, alcs. and heterocyclic compounds, and while it changed during storage, lipid oxidation products did not increase as expected, suggesting that rabbit meat may have relatively active reducing mechanisms. The experimental procedure involved many compounds, such as 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Application of 80-46-6

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