In general, the hydroxyl group makes alcohols polar. 141699-55-0, formula is C8H15NO3, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Application In Synthesis of 141699-55-0
Zhang, Hong;Ruiz-Castillo, Paula;Schuppe, Alexander W.;Buchwald, Stephen L. research published 《 Improved Process for the Palladium-Catalyzed C-O Cross-Coupling of Secondary Alcohols》, the research content is summarized as follows. An improved protocol for the Pd-catalyzed I C-O cross-coupling of secondary alcs. ROH (R = butan-2-yl, 2,2,2-trifluoro-1-phenylethyl, cyclopropyl(phenyl)methyl, etc.) is described. The use of biaryl phosphine as the ligand was key to achieving efficient cross-coupling of (hetero)aryl halides ArX (X = Cl, Br; Ar = 4-tert-butylphenyl, naphthalen-1-yl, 4-methylpyridin-2-yl, etc.) with only a 20% molar excess of the alc. Addnl., an unusual reactivity difference between an electron-rich aryl bromide and the analogus aryl chloride, and deuterium-labeling suggested that currently unidentified pathways for reduction play an important role in explaining this disparity were observed
141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.
Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., Application In Synthesis of 141699-55-0
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts