In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 141699-55-0, formula is C8H15NO3, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. Name: tert-Butyl 3-hydroxyazetidine-1-carboxylate
Wu, Xiaozeng;Cui, Yang research published 《 Synthesis of azetidine medicinal intermediate》, the research content is summarized as follows. Two ways in synthesis of pharmaceutical intermediate 1-(tert-butyl)-3-aminoazetidine were investigated by 1-(tert-butyl)-3-hydroxyazetidine as raw materials, sodium azide and phthalimide potassium salt as the ammonia source, and experiments operability, security, yield and post-processing level of them were studied. Experiments showed that when using azide as the ammonia source to replace the hydroxyl with azido, then adding zinc powder can be reduced to the product, obtained 70% yield. However, sodium azide may be toxic, the operation is more difficult due to its explosion when heat or vibration. When potassium phthalimide was used as the ammonia source, the product was obtained by hydrazinolysis the tert-ammonia solution in hydrazine hydrate. The yield was 63%, though lower than the former method, but the experiment could be operational very strong, safe and simple post-processing.
141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.
Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., Name: tert-Butyl 3-hydroxyazetidine-1-carboxylate
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts