SDS of cas: 7748-36-9, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 7748-36-9, name is Oxetan-3-ol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.
Wang, Le;Pratt, John K.;Soltwedel, Todd;Sheppard, George S.;Fidanze, Steven D.;Liu, Dachun;Hasvold, Lisa A.;Mantei, Robert A.;Holms, James H.;McClellan, William J.;Wendt, Michael D.;Wada, Carol;Frey, Robin;Hansen, T. Matthew;Hubbard, Robert;Park, Chang H.;Li, Leiming;Magoc, Terrance J.;Albert, Daniel H.;Lin, Xiaoyu;Warder, Scott E.;Kovar, Peter;Huang, Xiaoli;Wilcox, Denise;Wang, Rongqi;Rajaraman, Ganesh;Petros, Andrew M.;Hutchins, Charles W.;Panchal, Sanjay C.;Sun, Chaohong;Elmore, Steven W.;Shen, Yu;Kati, Warren M.;McDaniel, Keith F. research published 《 Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors》, the research content is summarized as follows. Members of the BET family of bromodomain containing proteins have been identified as potential targets for blocking proliferation in a variety of cancer cell lines. A 2-dimensional NMR fragment screen for binders to the bromodomains of BRD4 identified a Ph pyridazinone fragment with a weak binding affinity (I, Ki = 160 μM). SAR investigation of fragment I, aided by X-ray structure-based design, enabled the synthesis of potent pyridone and macrocyclic pyridone inhibitors exhibiting single digit nanomolar potency in both biochem. and cell based assays, e.g. II. Advanced analogs in these series exhibited high oral exposures in rodent PK studies and demonstrated significant tumor growth inhibition efficacy in mouse flank xenograft models.
7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., SDS of cas: 7748-36-9
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts