Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 16545-68-9, formula is C3H6O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , HPLC of Formula: 16545-68-9
Walker, Ann L.;Ancellin, Nicolas;Beaufils, Benjamin;Bergeal, Marylise;Binnie, Margaret;Clapham, David;Haslam, Carl P.;Holmes, Duncan S.;Hutchinson, Jonathan P.;Liddle, John;McBride, Andrew;Mirguet, Olivier;Mowat, Christopher G.;Rowland, Paul;Tiberghien, Nathalie;Trottet, Lionel;Uings, Iain;Webster, Scott P.;Zheng, Xiaozhong;Mole, Damian J. research published 《 Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis》, the research content is summarized as follows. Recently, we reported a novel role for KMO in the pathogenesis of acute pancreatitis (AP). A number of inhibitors of kynurenine 3-monooxygenase (KMO) have previously been described as potential treatments for neurodegenerative conditions and particularly for Huntington’s disease. However the inhibitors reported to date have insufficient aqueous solubility relative to their cellular potency to be compatible with the i.v. (i.v.) dosing route required in AP. We have identified and optimized a novel series of high affinity KMO inhibitors with favorable physicochem. properties. The leading example is exquisitely selective, has low clearance in two species, prevents lung and kidney damage in a rat model of acute pancreatitis and is progressing into preclin. development.
16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., HPLC of Formula: 16545-68-9
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts