Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 72824-04-5, formula is C9H17BO2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Formula: C9H17BO2
Tucker, Thomas J.;Embrey, Mark W.;Alleyne, Candice;Amin, Rupesh P.;Bass, Alan;Bhatt, Bhavana;Bianchi, Elisabetta;Branca, Danila;Bueters, Tjerk;Buist, Nicole;Ha, Sookhee N.;Hafey, Mike;He, Huaibing;Higgins, John;Johns, Douglas G.;Kerekes, Angela D.;Koeplinger, Kenneth A.;Kuethe, Jeffrey T.;Li, Nianyu;Murphy, BethAnn;Orth, Peter;Salowe, Scott;Shahripour, Aurash;Tracy, Rodger;Wang, Weixun;Wu, Chengwei;Xiong, Yusheng;Zokian, Hratch J.;Wood, Harold B.;Walji, Abbas research published 《 A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors》, the research content is summarized as follows. Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) is a key regulator of plasma LDL-cholesterol (LDL-C) and a clin. validated target for the treatment of hypercholesterolemia and coronary artery disease. Starting from second-generation lead structures such as 2, we were able to refine these structures to obtain extremely potent bi- and tricyclic PCSK9 inhibitor peptides. Optimized mols. such as 44 demonstrated sufficient oral bioavailability to maintain therapeutic levels in rats and cynomolgus monkeys after dosing with an enabled formulation. We demonstrated target engagement and LDL lowering in cynomolgus monkeys essentially identical to those observed with the clin. approved, parenterally dosed antibodies. These mols. represent the first report of highly potent and orally bioavailable macrocyclic peptide PCSK9 inhibitors with overall profiles favorable for potential development as once-daily oral lipid-lowering agents. In this manuscript, we detail the design criteria and multiparameter optimization of this novel series of PCSK9 inhibitors.
Formula: C9H17BO2, Allylboronic acid pinacol ester is a useful research compound. Its molecular formula is C9H17BO2 and its molecular weight is 168.04 g/mol. The purity is usually 95%.
Allylboronic acid pinacol ester is an allylation reagent that is used to produce aldehydes from ketones. It reacts with water, yielding the desired product and formaldehyde as a byproduct. The reaction proceeds through a sequence of steps, in which the boronate ester first reacts with water to form an allylboronate ion and hydrogen gas. This intermediate then reacts with potassium t-butoxide to produce the desired allyl alcohol and potassium borohydride. Finally, the palladium complex catalyst reduces the carbonyl group of the starting material, converting it into an aldehyde. Allylboronic acid pinacol ester is commercially available as a white solid, but can also be synthesized from 2-chloro-5-pinacolylborane (pinacol) in high yield using catalytic cross coupling reactions., 72824-04-5.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts