Application of C3H6O2, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 7748-36-9, name is Oxetan-3-ol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.
Riggs, Jennifer R.;Elsner, Jan;Cashion, Dan;Robinson, Dale;Tehrani, Lida;Nagy, Mark;Fultz, Kimberly E.;Krishna Narla, Rama;Peng, Xiaohui;Tran, Tam;Kulkarni, Ashutosh;Bahmanyar, Sogole;Condroski, Kevin;Pagarigan, Barbra;Fenalti, Gustavo;LeBrun, Laurie;Leftheris, Katerina;Zhu, Dan;Boylan, John F. research published 《 Design and optimization leading to an orally active TTK protein kinase inhibitor with robust single agent efficacy》, the research content is summarized as follows. Triple neg. breast cancer (TNBC) is an aggressive disease with high relapse rates and few treatment options. Outlined in previous publications, we identified a series of potent, dual TTK/CLK2 inhibitors with strong efficacy in TNBC xenograft models. Pharmacokinetic properties and kinome selectivity were optimized, resulting in the identification of a new series of potent, selective, and orally bioavailable TTK inhibitors. We describe here the structure-activity relationship of the 2,4-disubstituted-7H-pyrrolo[2,3-d]pyrimidine series, leading to significant single agent efficacy in a TNBC xenograft model without body weight loss. The design effort evolving an iv-dosed TTK/CLK2 inhibitor to an orally bioavailable TTK inhibitor is described.
7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Application of C3H6O2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts