On October 11, 2001, Muehlman, Anna; Classon, Bjoern; Hallberg, Anders; Samuelsson, Bertil published an article.Application of 72364-46-6 The title of the article was Synthesis of potent C2-symmetric, diol-based HIV-1 protease inhibitors. Investigation of thioalkyl and thioaryl P1/P1′ substituents. And the article contained the following:
The synthesis of novel, potent diol-based HIV-1 protease inhibitors, having either -SAr (Ar = Ph, 2-FC6H4, 2-pyridinyl, 2-thienyl), -SCH2Ar (Ar = Ph, 2-FC6H4), or -SCH2R (R = H2C:CHCH2) groups as P1/P1′ substituents is described. They can be prepared using a straightforward synthesis involving a thiol nucleophilic ring opening of a diepoxide. Inhibitor I, an indanyl(thiophenylsulfanyl)hexanediamide, was found to be a potent inhibitor of HIV-1 PR, showing good antiviral activity in a cell-based assay. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Application of 72364-46-6
The Article related to thioalkyl hexanediamide indanyl methylcarbamoylpropyl preparation hiv protease inhibitor, thioaryl hexanediamide indanyl methylcarbamoylpropyl preparation hiv protease inhibitor, hiv protease inhibitor thioaryl thioalkyl hexanediamide preparation, aids agent thioaryl thioalkyl hexanediamide and other aspects.Application of 72364-46-6
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