Ding, Qin’ge et al. published their research in Bioorganic Chemistry in 2020 |CAS: 111-29-5

The Article related to aminophenyl amino oxy phenylsulfonyl oxadiazole oxide preparation sar antitumor, antiproliferative hdac inhibitor aminophenyl oxy phenylsulfonyl oxadiazole oxide preparation, nitric oxide releasing aminophenyl oxy phenylsulfonyl oxadiazole oxide preparation, anticancer, histone deacetylase, hybrid, n-acyl-o-phenylenediamine, nitric oxide, phenylsulfonylfuroxan and other aspects.Name: Pentane-1,5-diol

On November 30, 2020, Ding, Qin’ge; Liu, Chunxi; Zhao, Chunlong; Dong, Hang; Xu, Qifu; James Chou, C.; Zhang, Yingjie published an article.Name: Pentane-1,5-diol The title of the article was Synthesis and biological study of class I selective HDAC inhibitors with NO releasing activity. And the article contained the following:

Based on the multi-mechanism antitumor strategy and the regulatory effect of nitric oxide (NO) on histone deacetylases (HDACs), a series of N-acyl-o-phenylenediamine-based HDAC inhibitors equipped with the phenylsulfonylfuroxan module I [R = Pr, Bu, n-pentyl, etc.] as NO donor was designed, synthesized and biol. evaluated. The in vitro HDAC inhibitory assays revealed that compared with the clin. class I selective HDAC inhibitor MS275, compounds I [R = n-pentyl, n-hexyl, n-heptyl] possessed similar HDAC inhibitory potency and selective profile, which were confirmed by the results of western blot anal. The western blot anal. also showed that NO scavenger N-acetyl cysteine (NAC) could weaken the intracellular HDAC inhibitory ability of compound I [R = n-pentyl] supported the HDAC inhibitory effect of NO generated by compound I [R = n-pentyl]. Compounds I [R = n-pentyl, n-hexyl, n-heptyl] exhibited more potent in vitro antiproliferative activities than MS275 against all four tested solid tumor cell lines. The promising in vivo antitumor potency of compound I [R = n-pentyl] was demonstrated in a HCT116 xenograft model. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Name: Pentane-1,5-diol

The Article related to aminophenyl amino oxy phenylsulfonyl oxadiazole oxide preparation sar antitumor, antiproliferative hdac inhibitor aminophenyl oxy phenylsulfonyl oxadiazole oxide preparation, nitric oxide releasing aminophenyl oxy phenylsulfonyl oxadiazole oxide preparation, anticancer, histone deacetylase, hybrid, n-acyl-o-phenylenediamine, nitric oxide, phenylsulfonylfuroxan and other aspects.Name: Pentane-1,5-diol

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