Formula: C8H15NO3, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.
Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.
With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 141699-55-0, formula is C8H15NO3, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Formula: C8H15NO3
Isakovic, Ljubomir;Saavedra, Oscar M.;Llewellyn, David B.;Claridge, Stephen;Zhan, Lijie;Bernstein, Naomy;Vaisburg, Arkadii;Elowe, Nadine;Petschner, Andrea J.;Rahil, Jubrail;Beaulieu, Norman;Gauthier, France;MacLeod, A. Robert;Delorme, Daniel;Besterman, Jeffrey M.;Wahhab, Amal research published 《 Constrained (-)-S-adenosyl-L-homocysteine (SAH) analogues as DNA methyltransferase inhibitors》, the research content is summarized as follows. Potent SAH analogs with constrained homocysteine units have been designed and synthesized as inhibitors of human DNMT enzymes. The five membered (2S,4S)-4-mercaptopyrrolidine-2-carboxylic acid, in I, was a good replacement for homocysteine, while the corresponding six-member counterpart was less active. Further optimization of I, changed the selectivity profile of these inhibitors. II, resulting from a chloro substitution at the 2-position of I, retained potency against DNMT1; while III, resulting from N6 alkylation, conserved DNMT3b2 activity. The concomitant substitutions of I at both 2- and N6 positions reduced activity against both enzymes.
Formula: C8H15NO3, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.
Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts