Application In Synthesis of 7748-36-9, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 7748-36-9, name is Oxetan-3-ol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.
Hie, Liana;Fine Nathel, Noah F.;Shah, Tejas K.;Baker, Emma L.;Hong, Xin;Yang, Yun-Fang;Liu, Peng;Houk, K. N.;Garg, Neil K. research published 《 Conversion of amides to esters by the nickel-catalysed activation of amide C-N bonds》, the research content is summarized as follows. Amides are common functional groups that have been studied for more than a century. They are the key building blocks of proteins and are present in a broad range of other natural and synthetic compounds Amides are known to be poor electrophiles, which is typically attributed to the resonance stability of the amide bond. Although amides can readily be cleaved by enzymes such as proteases, it is difficult to selectively break the carbon-nitrogen bond of an amide using synthetic chem. Here we demonstrate that amide carbon-nitrogen bonds can be activated and cleaved using nickel catalysts. We use this methodol. to convert amides to esters, which is a challenging and underdeveloped transformation. The reaction methodol. proceeds under exceptionally mild reaction conditions, and avoids the use of a large excess of an alc. nucleophile. DFT calculations provide insight into the thermodn. and catalytic cycle of the amide-to-ester transformation. Our results provide a way to harness amide functional groups as synthetic building blocks and are expected to lead to the further use of amides in the construction of carbon-heteroatom or carbon-carbon bonds using non-precious-metal catalysis.
7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Application In Synthesis of 7748-36-9
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts