In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 72824-04-5, formula is C9H17BO2, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. Formula: C9H17BO2
Henley, Zoe A.;Amour, Augustin;Barton, Nick;Bantscheff, Marcus;Bergamini, Giovanna;Bertrand, Sophie M.;Convery, Maire;Down, Kenneth;Dumpelfeld, Birgit;Edwards, Chris D.;Grandi, Paola;Gore, Paul M.;Keeling, Steve;Livia, Stefano;Mallett, David;Maxwell, Aoife;Price, Mark;Rau, Christina;Reinhard, Friedrich B. M.;Rowedder, James;Rowland, Paul;Taylor, Jonathan A.;Thomas, Daniel A.;Hessel, Edith M.;Hamblin, J. Nicole research published 《 Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target》, the research content is summarized as follows. Optimization of a lead series of PI3Kδ inhibitors based on a dihydroisobenzofuran core led to the identification of potent, orally bioavailable compound 19. Selectivity profiling of compound 19 showed similar potency for class III PI3K, Vps34, and PI3Kδ, and compound 19 was not well-tolerated in a 7-day rat toxicity study. Structure-based design led to an improvement in selectivity for PI3Kδ over Vps34 and, a focus on oral phramacokinetics properties resulted in the discovery of compound 41, which showed improved toxicol. outcomes at similar exposure levels to compound 19.
72824-04-5, Allylboronic acid pinacol ester is a useful research compound. Its molecular formula is C9H17BO2 and its molecular weight is 168.04 g/mol. The purity is usually 95%.
Allylboronic acid pinacol ester is an allylation reagent that is used to produce aldehydes from ketones. It reacts with water, yielding the desired product and formaldehyde as a byproduct. The reaction proceeds through a sequence of steps, in which the boronate ester first reacts with water to form an allylboronate ion and hydrogen gas. This intermediate then reacts with potassium t-butoxide to produce the desired allyl alcohol and potassium borohydride. Finally, the palladium complex catalyst reduces the carbonyl group of the starting material, converting it into an aldehyde. Allylboronic acid pinacol ester is commercially available as a white solid, but can also be synthesized from 2-chloro-5-pinacolylborane (pinacol) in high yield using catalytic cross coupling reactions., Formula: C9H17BO2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts