《Silver-Mediated N-Trifluoromethylation of Amides and Peptides》 was published in Chinese Journal of Chemistry in 2020. These research results belong to Zhang, Zhenzhen; He, Jiayan; Zhu, Lin; Xiao, Haiwen; Fang, Yewen; Li, Chaozhong. Related Products of 20880-92-6 The article mentions the following:
The direct N-trifluoromethylation of N-H amides was reported. Promoted by AgOTf and 2-fluoropyridine, the reaction of a variety of amides with Selectfluor, TMSCF3 and CsF proceeded smoothly at room temperature leading to the corresponding N-trifluoromethylated products in satisfactory yields. The protocol was also applicable to amino acid derivatives, resulting in efficient and chemoselective N-trifluoromethylation of di- and tri-peptides with retention of configuration. A mechanism involving reductive elimination of Ag(III) intermediates to form N-CF3 bonds was proposed. In the experimental materials used by the author, we found ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Related Products of 20880-92-6)
((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II (CA-II).Related Products of 20880-92-6 And it is used as chiral auxiliaries in Michael and Aldol addition reactions.
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