Zhang, Yu; Qin, Shaowei; Claes, Nathalie; Schilling, Waldemar; Sahoo, Prakash Kumar; Ching, H. Y. Vincent; Jaworski, Aleksander; Lemiere, Filip; Slabon, Adam; Van Doorslaer, Sabine; Bals, Sara; Das, Shoubhik published the artcile< Direct Solar Energy-Mediated Synthesis of Tertiary Benzylic Alcohols Using a Metal-Free Heterogeneous Photocatalyst>, Reference of 76-84-6, the main research area is tertiary benzylic alc preparation; carbon hydrogen bond hydroxylation photocatalyst solar energy.
Direct hydroxylation via the functionalization of tertiary benzylic C(sp3)-H bonds is of great significance for obtaining tertiary alcs., which find wide applications in pharmaceuticals as well as in fine chem. industries. However, current synthetic procedures use toxic reagents, and therefore, the development of a sustainable strategy for the synthesis of tertiary benzylic alcs. is highly desirable. To solve this problem, herein, a metal-free heterogeneous photocatalyst to synthesize the hydroxylated products using oxygen as the key reagent is reported. Various benzylic substrates were employed into the mild reaction conditions to afford the desirable products in good to excellent yields. More importantly, the gram-scale reaction was achieved via harvesting direct solar energy and exhibited high quantity of the product. The high stability of the catalyst was proved via recycling the catalyst and spectroscopic analyses. Finally, a possible mechanism was proposed based on the ESR and other exptl. evidence.
ACS Sustainable Chemistry & Engineering published new progress about Aromatic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Reference of 76-84-6.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts