The author of 《Design and synthesis a mitochondria-targeted dihydronicotinamide as radioprotector》 were Zhang, Yu-Rui; Wang, Jun-Ying; Li, Yuan-Yuan; Meng, Yuan-Yuan; Zhang, Yuan; Yang, Fu-Jun; Xu, Wen-Qing. And the article was published in Free Radical Biology & Medicine in 2019. Reference of 3-Bromopropan-1-ol The author mentioned the following in the article:
Radiation-induced damage to the mitochondrial macromols. and electron transfer chain (ETC), causing the generation of primary and secondary reactive oxygen (ROS) species. The continuous ROS production after radiation will trigger cell oxidative stress and ROS-mediated nucleus apoptosis and autophagy signaling pathways. Scavenging radiation-induced ROS effectively can help mitochondria to maintain their physiol. function and relief cells from oxidative stress. Nicotinamide is a critical endogenous antioxidant helping to neutralize ROS in vivo. In this study, we designed and synthesized a novel mitochondrial-targeted dihydronicotinamide (Mito-N) with the help of mitochondrial membrane potential to enter the mitochondria and scavenge ROS. According to experiment results, Mito-N significantly increased cell viability by 30.75% by neutralizing the accumulated ROS and resisting DNA strands breaks after irradiation Furthermore, the mice survival rate also improved with the treatment of Mito-N, by effectively ameliorating the hematopoietic system infliction under LD irradiation In the experiment, the researchers used 3-Bromopropan-1-ol(cas: 627-18-9Reference of 3-Bromopropan-1-ol)
3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Reference of 3-Bromopropan-1-ol
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