HPLC of Formula: 7748-36-9In 2021 ,《Copper-catalyzed ortho-selective direct sulfenylation of N-aryl-7-azaindoles with disulfides》 was published in Organic & Biomolecular Chemistry. The article was written by Yu, Ru-Jian; Zhang, Chun-Yan; Xiang, Zhou; Xiong, Yan-Shi; Duan, Xue-Min. The article contains the following contents:
A copper-catalyzed direct C-H chalcogenation of N-aryl-azaindoles I (R = H, Me, Cl, etc.; R1 = H, Me, OMe, CF3; R2 = CH or N) with disulfides R3SSR3 (R3 = Ph, thiophen-2-yl, Pr, cyclohexyl, etc.), 1-thiophen-2-yl-1H-pyrrolo[2,3-b]pyridine is described. This transformation was performed using Earth abundant Cu(OAc)2 as a catalyst, benzoic acid as an additive, air as a terminal oxidant, and readily available diaryl and dialkyldisulfides (or (phenyldiselanyl)benzene) as chalcogenation reagents. High functional group tolerance and excellent regioselectivity are demonstrated by the efficient preparation of a wide range of ortho-sulfenylation-7-azaindoles II (X = S or Se), 1-(3-(phenylthio)thiophen-2-yl)-1H-pyrrolo[2,3-b]pyridine. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9HPLC of Formula: 7748-36-9)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.HPLC of Formula: 7748-36-9
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