Xu, Xiangchao; Ai, Yao; Wang, Rongzhou; Liu, Liping; Yang, Jiazhi; Li, Feng published the artcile< Ruthenium-catalyzed acceptorless dehydrogenative coupling of o-aminobenzyl alcohols with ketones to quinolines in the presence of carbonate salt>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is quinoline preparation green chem; aminobenzyl alc ketone acceptorless dehydrogenative coupling ruthenium catalyst.
A ruthenium complex bearing a functional 2,2′-bibenzimidazole ligand [(p-cymene)Ru(BiBzImH2)Cl][Cl] was designed, synthesized and found to be a general and highly efficient catalyst for the synthesis of quinolines I [R = H, Cl, Br; R1 = H, F, Cl, Me, OMe; R2 = t-Bu, cyclopropyl, Ph, pyrazin-2-yl, etc.; R3 = H, Me, Et] and 5,6-dihydrobenzo[c]acridine via acceptorless dehydrogenative coupling of o-aminobenzyl alcs. 2-NH2-4-R-5-R1-C6H2CH2OH with ketones R2C(O)CH2R3 and 1-tetralone in the presence of carbonate salt. It was confirmed that NH units in the ligand are crucial for catalytic activity. The application of this catalytic system for the scale-gram synthesis of biol. active mol. was also undertaken. Notably, this research exhibits new potential of metal-ligand bifunctional catalysts for acceptorless dehydrogenative reactions.
Journal of Catalysis published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts