Xing, Wei-Long; Wang, Jia-Xin; Fu, Ming-Chen; Fu, Yao published an article on February 1 ,2022. The article was titled 《Efficient Decarboxylative/Defluorinative Alkylation for the Synthesis of gem-Difluoroalkenes through an SN2′ Type Route》, and you may find the article in Chinese Journal of Chemistry.Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol The information in the text is summarized as follows:
An efficient decarboxylative/defluorinative alkylation for synthesizing gem-difluoroalkenes F2C:CRCH2CR1R2R3 [R = 4-PhC6H4, naphthalen-2-yl, 1-methyl-1H-indol-5-yl, etc.; R1 = H, Me, Et; R2 = H, Me, Et, Ph, etc.; R1R2 = (CH2)3; R3 = Ph, CN, COOEt, etc.] is described, providing a general method for installation of the challenging alkyl fragments containing γ-electron-withdrawing groups into γ-trifluoromethyl alkenes RC(CF3):CH2. Mechanistic studies suggest that this process involves an SN2′-type synthetic route in the absence of transition-metal catalysts or photocatalysis. Moreover, this protocol can easily be scaled up, and successfully applied to the modification of biol. active mols., thus complementing methodologies that give access to structurally versatile gem-difluoroalkenes. The experimental process involved the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol)
((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II (CA-II). And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol
Referemce:
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