SDS of cas: 6346-09-4On October 15, 2021 ,《Ozone-Mediated Amine Oxidation and Beyond: A Solvent-Free, Flow-Chemistry Approach》 was published in Journal of Organic Chemistry. The article was written by Skrotzki, Eric A.; Vandavasi, Jaya Kishore; Newman, Stephen G.. The article contains the following contents:
Ozone is a powerful oxidant, most commonly used for oxidation of alkenes to carbonyls. The synthetic utility of other ozone-mediated reactions is hindered by its high reactivity and propensity to overoxidize organic mols., including most solvents. This challenge can largely be mitigated by adsorbing both substrate and ozone onto silica gel, providing a solvent-free oxidation method. In this manuscript, a flow-based packed bed reactor approach is described that provides exceptional control of reaction temperature and time to achieve improved control and chemoselectivity over this challenging transformation. A powerful method to oxidize primary amines into nitroalkanes is achieved. Examples of pyridine, C-H bond, and arene oxidations are also demonstrated, confirming the system is generalizable to diverse ozone-mediated processes.4,4-Diethoxybutan-1-amine(cas: 6346-09-4SDS of cas: 6346-09-4) was used in this study.
4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.SDS of cas: 6346-09-4
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