Sivakumar, Ganesan; Subaramanian, Murugan; Balaraman, Ekambaram published the artcile< Single-Molecular Mn(I)-Complex-Catalyzed Tandem DoubleDehydrogenative Cross-Coupling of (Amino)Alcohols under Solventless Conditions with the Liberation of H2 and H2O>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is quinoline pyridine preparation green; primary amino alc double dehydrogenative cross coupling manganese.
Sustainable chem. production requires fundamentally new types of catalysts and catalytic technologies. The development of coherent and robust catalytic systems based on earth-abundant transition metals is essential but extremely challenging. Herein, authors report the first report on a single Mn(I)-PNP catalyzed tandem C-C and C-N bond formation via double dehydrogenative coupling of amino alcs. with primary alcs. The current method covers a wide range of substrates, including aryl, aliphatic acyclic, and cyclic primary alcs., as well as amino alcs., to provide diverse N-heterocyclic compounds (pyridine and quinoline derivatives) in good to excellent yields (50 examples). The reaction proceeds under benign, solventless conditions with the liberation of mol. hydrogen and water as the only byproducts. Various control and labeling experiments and kinetic, NMR, and mechanistic studies suggest that the reaction operates via the acceptorless double dehydrogenative coupling pathway, selectively assimilating to provide desired N-heterocycles. Several selective bond activation/formation reactions occur sequentially via amine-amide metal-ligand cooperation.
ACS Sustainable Chemistry & Engineering published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts