《Synthesis, biological evaluation and molecular docking study of dihydropyrimidine derivatives as potential anticancer agents》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Safari, Sahand; Ghavimi, Reza; Razzaghi-Asl, Nima; Sepehri, Saghi. Application of 100-83-4 The article mentions the following:
A series of dihydropyrimidine analogs I (R = H, 3-Cl, 2-OH, 4-NO2, etc.; R1 = Et, Ph; X = O, S) was prepared via one-pot Biginelli three-component condensation reaction. Subsequently, they were screened for in vitro anticancer effect. These analogs revealed good cytotoxic activity against three human cancer cell lines including MCF-7, HepG-2, and A549. Among these analogs, compounds I (R = H, R1 = Ph, X = S (A); R = 4-NO2, R1 = Ph, X = S (B)) were the most potent against three cell lines. Cell viability assays indicated that I (R = H, R1 = Ph, X = O; R = 2-OH, R1 = Ph, X = O) had lower cytotoxicity. In vitro cytotoxicity study on all synthesized compounds demonstrated that introduction of electron withdrawing substituents on C4 position of Ph ring of dihydropyrimidine contributed to the antiproliferative potency. Moreover, in silico mol. docking results stipulated a sign of good correlation between exptl. activity and calculated binding affinity. It proved (A) and (B) as the strongest compounds Binding modes of analogs proposed the involvement of hydrophobic interactions and hydrogen bonds with Eg5 active site. Structure activity relationship studies indicated that incorporating electron withdrawing substituents on C4 position of Ph ring of dihydropyrimidine are important for this biol. activity. After reading the article, we found that the author used 3-Hydroxybenzaldehyde(cas: 100-83-4Application of 100-83-4)
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Application of 100-83-4
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