Pollastri, Sara; Delaunay, Clara; Thepaut, Michel; Fieschi, Franck; Bernardi, Anna published the artcile< Glycomimetic ligands block the interaction of SARS-CoV-2 spike protein with C-type lectin co-receptors>, Category: alcohols-buliding-blocks, the main research area is glycomimetic ligand synthesis L SIGN SARSCoV2 coronavirus spike protein.
The C-type lectin receptors DC-SIGN and L-SIGN bind to glycans on the SARS-CoV-2 spike glycoprotein and promote trans-infection of ACE2-expressing cells. We tested C2 triazole-modified mono- and pseudo-di-mannosides as inhibitors of DC/L-SIGN binding to a model mannosylated protein (Man-BSA) and to SARS-CoV2 spike, finding that they inhibit the interaction of both lectins with the spike glycoprotein in a Surface Plasmon Resonance (SPR) assay and are more potent than mannose by up to 36-fold (DC-SIGN) and 10-fold (L-SIGN). The mols. described here are the first known glycomimetic ligands of L-SIGN.
Chemical Communications (Cambridge, United Kingdom) published new progress about Anticoronaviral agents. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Category: alcohols-buliding-blocks.
Referemce:
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Alcohols – Chemistry LibreTexts