Park, Ji Yong; Kim, Young Joo; Lee, Ji Youn; Lee, Yun-Sang; Jeong, Jae Min published the artcile< Imaging of the third gasotransmitter hydrogen sulfide using 99mTc-labeled alpha-hydroxy acids>, SDS of cas: 87-73-0, the main research area is alpha hydroxy acid 99mTc hydrogen sulfide gasotransmitter imaging; Glucoheptonate; Gluconate; H(2)S; Hypoxia; Inflammation; Ischemia; Technetium.
Various α-hydroxy acids such as glycolate, L-lactate, D-lactate, D-gluconate, D-glucoheptonate, D-glucuronate, D-glucarate, and citrate were labeled with 99mTc in the presence of stannous chloride. The labeled compounds were incubated with 0.2 mM of NaHS, and reactive sulfur species and then analyzed by ITLC/normal saline to detect the formation of insoluble complex. Matrigels containing various concentrations of NaHS were xenografted on the shoulder of normal mice, and an imaging study was performed after i.v. injection of [99mTc]Tc-gluconate. We also obtained autoradiog. image of a rat brain with a temporary brain ischemia after i.v. injection of [99mTc]Tc-gluconate.[99mTc]Tc-gluconate showed the highest formation of insoluble complex (87.8 ± 3.6%) after incubation with 0.2 mM NaHS. The Matrigel containing 2μmol NaHS showed uptake of [99mTc]Tc-gluconate, which proved the feasibility as the specific H2S imaging agent in vivo. Temporary ischemic lesion of rat brain showed high radioactivity accumulation representing the feasibility as endogenous H2S imaging agents. We proved that 99mTc-labeled α-hydroxy acid especially [99mTc]Tc-gluconate is a novel endogenous H2S imaging agent, which might contribute to study and diagnosis of various diseases related with inflammation and hypoxia.
Nuclear Medicine and Biology published new progress about Brain. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, SDS of cas: 87-73-0.
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