《DNA-Targeted NO Release Photoregulated by Green Light》 was written by Parisi, Cristina; Fraix, Aurore; Guglielmo, Stefano; Spyrakis, Francesca; Rolando, Barbara; Lazzarato, Loretta; Fruttero, Roberta; Gasco, Alberto; Sortino, Salvatore. COA of Formula: C3H9NO And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:
A novel mol. hybrid has been designed and synthesized in which acridine orange (AO) is covalently linked to an N-nitrosoaniline derivative through an alkyl spacer. Photoexcitation of the AO antenna with the highly biocompatible green light results in intense fluorescence emission and triggers NO detachment from the N-nitroso appendage via an intramol. electron transfer. The presence of the AO moiety encourages the binding with DNA through both external and partially intercalative fashions, depending on the DNA:mol. hybrid molar ratio. Importantly, this dual-mode binding interaction with the biopolymer does not preclude the NO photoreleasing performances of the mol. hybrid, permitting NO to be photogenerated nearby DNA with an efficiency similar to that of the free mol. These properties make the presented compound an intriguing candidate for fundamental and potential applicative research studies where NO delivery in the DNA proximity precisely regulated by harmless green light is required. In the experiment, the researchers used many compounds, for example, 3-Aminopropan-1-ol(cas: 156-87-6COA of Formula: C3H9NO)
3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.COA of Formula: C3H9NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts