Pandey, Akanksha M.; Digrawal, Naveen Kumar; Mohanta, Nirmala; Jamdade, Akash Bandu; Chaudhari, Moreshwar B.; Bisht, Girish Singh; Gnanaprakasam, Boopathy published the artcile< Catalytic Acceptorless Dehydrogenation of Amino Alcohols and 2-Hydroxybenzyl Alcohols for Annulation Reaction under Neutral Conditions>, Quality Control of 5344-90-1, the main research area is dicarbonyl amino alc domino enamine ruthenium oxidative cyclization green; tetrahydroindole preparation; tetrahydroacridinone preparation; hydroxybenzyl alc dicarbonyl ruthenium alkylation cyclization dehydrogenation condensation hydrogenation; tetrahydroxanthenone preparation.
A base-free and acceptorless Ru-catalyzed dehydrogenative approach has been developed for the synthesis of N-heterocycles by using 1,3-dicarbonyls and amino alcs. through a domino sequential enamine formation and intramol. oxidative cyclization strategy. This unified approach is also applicable for the synthesis of O-heterocycles involving 2-hydroxybenzyl alc. as a coupling reactant via consecutive C-alkylation and intramol. cyclization steps. The present protocol is general for the synthesis of varieties of biol. important scaffolds, such as tetrahydro-4H-indol-4-one, 3,4-dihydroacridin-1(2H)-one, and tetrahydro-1H-xanthen-1-ones derivatives using a single catalytic system, viz. RuH2CO(PPh3)3. Environmentally benign H2O and H2 are the only byproducts in this domino process. Moreover, RuH2CO(PPh3)3-catalyzed C3-alkylation of tetrahydro-4H-indol-4-one using alc. as a alkylating partner is also described in this report. For the first time, a solvent-free gram-scale reaction for the acceptorless dehydrogenative annulation has been demonstrated. A plausible mechanism for the Ru-catalyzed base-free and acceptorless dehydrogenative annulation of amino alcs. or 2-hydroxybenzyl alcs. has been provided with several exptl. investigations and spectroscopic evidence.
Journal of Organic Chemistry published new progress about Acridines Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation) (tetrahydroacridinone). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Quality Control of 5344-90-1.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts