Ochiai, Asako; Kuroda, Keiji published the artcile< Preconception resveratrol intake against infertility: Friend or foe>, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review endometriosis infertility resveratrol; aging; assisted reproductive technology; infertility; resveratrol; sirtuin.
A review. Growing evidence indicates that resveratrol has potential therapeutic effects in infertile women with diminished ovarian function, polycystic ovary syndrome (PCOS), or endometriosis. However, only one clin. trial in women undergoing in vitro fertilization (IVF) cycles using resveratrol has ever been reported. This review focuses on the potential therapeutic effects of resveratrol on pregnancy and on its advantages and disadvantages in pregnancy outcomes during infertility treatment. Methods : We performed a literature review to describe the known impacts of resveratrol on the ovary and endometrium. Results : Resveratrol upregulates sirtuin (SIRT)1 expression in ovaries, which is associated with protection against oxidative stress. It leads to the activation of telomerase activity and mitochondrial function, improving ovarian function. In the endometrium, resveratrol downregulates the CRABP2-RAR pathway leading to suppressing decidual and senescent changes of endometrial cells, which is essential for embryo implantation and placentation. Moreover, resveratrol may also induce deacetylation of important decidual-related genes. Conclusions : Resveratrol has potential therapeutic effects for improving ovarian function; however, it also has anti-deciduogenic actions in uterine endometrium. In addition, its teratogenicity has not yet been ruled out; thus, resveratrol should be avoided during the luteal phase and pregnancy.
Reproductive Medicine and Biology published new progress about Embryo, animal, two-cell. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.
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