Niu, Junfeng; Wang, Shangping; Wang, Bulei; Chen, Lijun; Zhao, Guangming; Liu, Shuai; Wang, Shiqiang; Wang, Zhezhi published the artcile< Structure and anti-tumor activity of a polysaccharide from Bletilla ochracea Schltr.>, Application In Synthesis of 3458-28-4, the main research area is Bletilla polysaccharide structure antitumor activity; Anti-tumor; Bletilla ochracea; Immuno-modulation; Polysaccharide; Structure.
The polysaccharide fraction of Bletilla ochracea (BOP) was isolated from its tubers, and purified by DEAE-52 Cellulose and Sephadex G-200 column chromatog. The structural features of BOP were analyzed by GC-MS, HPLP, FT-IR, methylation and NMR. The average mol. weight of BOP was approx. 4.9 × 105 Da, and the monosaccharide composition was 7.88:2.12 mix of mannose and glucose. Although BOP had no effect on the proliferation rate of CT26 colon carcinoma cells, it significantly inhibited tumor xenograft growth in vivo by stimulating CD4+ T cell expansion in the spleen of the tumor-bearing mice. Taken together, BOP is a potent immunomodulatory agent that can be considered for anti-tumor therapy.
International Journal of Biological Macromolecules published new progress about Antitumor agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application In Synthesis of 3458-28-4.
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