In 2018,Nitha, P. R.; Joseph, Manu M.; Gopalan, Greeshma; Maiti, Kaustabh Kumar; Radhakrishnan, K. V.; Das, Parthasarathi published 《Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo[1,2-a]pyridines》.Organic & Biomolecular Chemistry published the findings.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The information in the text is summarized as follows:
A palladium-catalyzed aminocarbonylation strategy exploiting chloroform as a CO source has been developed for the synthesis of biol. potent 2-amidoimidazopyridine I (R1, R2 = -(CH2)4-, -(CH2)5-, cyclohexyl, etc.) scaffolds. The aminocarbonylation reaction was found to be general with a range of amines and substituted imidazopyridines. Preliminary biol. evaluation of cytotoxicity on selected examples provides scope for future investigations. In the part of experimental materials, we found many familiar compounds, such as (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)
(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol
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