Computed Properties of C3H6O2In 2021 ,《Synthesis of Terminal N-Vinylazoles from Aromatic Aldehydes, DMSO, and Azoles Based DMSO as Terminal Carbon Synthon》 was published in Advanced Synthesis & Catalysis. The article was written by Nie, Zhiwen; Lv, Huifang; Li, Hui; Su, Miaodong; Yang, Tonglin; Luo, Weiping; Liu, Qiang; Guo, Cancheng. The article contains the following contents:
A protocol for the synthesis of terminal N-vinylazoles such as H2C=CR1R [R = indol-1-yl, pyrrol-1-yl, pyrazol-1-yl, etc.; R1 = Ph, 2-MeC6H4, 4-FC6H4, etc.] from aromatic aldehydes, DMSO and azoles was reported. The scope of aldehydes and amides for preparation of enamides I [Ar = Ph, 4-ClC6H4, 4-tBuC6H4, etc.; n = 1, 2] was also reported. In this strategy, DMSO was involved in the construction of the C=C bond as a terminal carbon synthon. Both aromatic aldehydes and azoles could be well tolerated and gave the corresponding terminal N-vinylazoles in 52-91% yields. Based on preliminary experiments, a plausible mechanism was proposed. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Computed Properties of C3H6O2)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Computed Properties of C3H6O2
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