Nandy, Anuradha; Kazi, Imran; Guha, Somraj; Sekar, Govindasamy published their research in Journal of Organic Chemistry in 2021. The article was titled 《Visible-Light-Driven Halogen-Bond-Assisted Direct Synthesis of Heteroaryl Thioethers Using Transition-Metal-Free One-Pot C-I Bond Formation/C-S Cross-Coupling Reaction》.Category: alcohols-buliding-blocks The article contains the following contents:
An efficient protocol for the synthesis of thioether directly from heteroarenes was developed in the presence of visible light in a one-pot manner at room temperature This method involved two sequential reactions in a single pot where the formation of the iodinated heteroarene was followed by a transition-metal-free C-S coupling reaction. A wide range of heteroarene and thiol partners (including aliphatic thiols) was used for the synthesis of thioethers. NMR studies and DFT calculations revealed the presence of a halogen bond between the thiolate anion (halogen bond acceptor) and iodoheteroarene (halogen bond donor). This halogen bonded complex on photoexcitation facilitated the electron transfer from the thiolate anion to the iodoheteroarene at room temperature After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Category: alcohols-buliding-blocks)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts