Mutlu Balci, Ceylan; Palabiyik, Duygu; Besli, Serap published their research in Inorganica Chimica Acta in 2021. The article was titled 《Amino alcohol based cyclotriphosphazenes: Effects of chain length and base factor on product diversity》.Reference of 4-Aminobutan-1-ol The article contains the following contents:
The effects of chain length and base on product diversity in the reactions of hexachlorocyclotriphosphazene, N3P3Cl6 (1) with amino alcs. (2a and 2b) were reported. In this sense, two different amino alcs. (2a and 2b) and three different base solutions (Et3N, NaH and amino alc. itself) were selected. All reactions were performed at 1:1 mol ratio in THF solvent and under argon atm. These reactions led to formation of open chain (3a, 3b and 7b) and spiro (4a-6a and 4b) compounds The isolated compounds (3a-5a, 3b, 4b and 7b) were characterized by elemental anal., MALDI-TOF mass spectrometry, 1H, and 31P NMR spectroscopy. The mol. and crystal structures of 4a, 5a and 4b were illuminated by X-Ray crystallog. The product formations and their amounts were discussed in terms of two different aspects: chain length of the nucleophile and the role of base. In addition, the product varieties in the reactions of hexachlorocyclotriphosphazene with diols, diamines and amino alcs. were mentioned. The results came from multiple reactions, including the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Reference of 4-Aminobutan-1-ol)
4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Reference of 4-Aminobutan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts