Michalak, Michal; Bisek, Bartosz; Nowacki, Michal; Gorecki, Marcin published the artcile< Base-Catalyzed, Solvent-Free Synthesis of Rigid V-Shaped Epoxydibenzo[b,f][1,5]diazocines>, Product Details of C4H8O, the main research area is fluorinated aminophenone tetramethylguanidine catalyst autocondensation cross condensation; epoxydibenzo diazocine preparation.
A novel method for the synthesis of epoxydibenzo[b,f][1,5]diazocines exhibiting a V-shaped mol. architecture is reported. The unique approach is based on unprecedented base-catalyzed, solvent-free autocondensation and cross-condensation of fluorinated o-aminophenones. The structure of the newly synthesized diazocines was confirmed independently by X-ray anal. and chiroptical methods. The rigidity of the diazocine scaffold allowed for the separation of the racemate into single enantiomers that proved to be thermally stable up to 140°C. Furthermore, the inertness of the diazocine scaffold was demonstrated by performing a series of typical transformations, including transition metal-catalyzed reactions, proceeding without affecting the bis-hemiaminal subunit.
Journal of Organic Chemistry published new progress about Condensation reaction. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Product Details of C4H8O.
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