Meng, Xiangtai; Chen, Dengfeng; Liu, Rui; Jiang, Ping; Huang, Shenlin published the artcile< Synthesis of 2-(Cyanomethyl)benzoic Esters via Carbon-Carbon Bond Cleavage of Indanones>, Related Products of 627-27-0, the main research area is cyanomethyl benzoic ester preparation; indanone alc bond cleavage.
A novel synthesis of 2-(cyanomethyl)benzoic esters 2-C(R)CN-3-R1-4-R2-5-R3C6HC(O)OR4 (R = H, Me; R1 = H, Br, CN, CF3; R2 = H, Br, OMe, Cl, etc.; R3 = H, Me, OMe, Br; R4 = Me, Bn, furan-2-ylmethyl, 2H-1,3-benzodioxol-5-ylmethyl, etc.) and ethyl2-(3-cyanopropyl)benzoate from indanone derivatives I (R5 = Me, Ph, 4-trifluoromethylphenyl) and [5-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-ylidene]amino acetate has been established. This reaction proceeds via a deprotonation of alcs. R4OH with a chem. base, followed by a nucleophilic addition to indanones I and Beckmann fragmentation. In addition, this reaction could also work under electrochem. conditions, and no external chem. bases were needed. This mild method offers a novel strategy for the late-stage functionalization of various natural alcs. such as citronellol, nerol, abietyl alc., etc.
Journal of Organic Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Related Products of 627-27-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts